Daclatasvir and asunaprevir treatment in patients infected by genotype 1b of hepatitis C virus with no or subtle resistant associated substitutions (RAS) in NS5A‐Y93
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DOI: 10.1002/jmv.24978
Abstract: In this study, we investigated the real‐world data of the first approved interferon‐free regimen in Japan, daclatasvir and asunaprevir (DCV+ASV), in chronic hepatitis C patients infected HCV genotype 1b with no or subtle amount of… read more here.
Keywords: resistant associated; treatment; daclatasvir asunaprevir; associated substitutions ... See more keywords
Prevalence of NS5A resistance associated substitutions in patients with hepatitis C virus genotypes 1a and 3: Impact on current therapeutic strategies
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DOI: 10.1002/jmv.25048
Abstract: The presence of resistance‐associated substitutions (RASs) at NS5A region might compromise the efficacy of Direct Acting Antiviral agents (DAAs). HCV resistance at NS5A region is mainly focused on patients with hepatitis C virus (HCV) genotypes… read more here.
Keywords: g1a; rass; prevalence; associated substitutions ... See more keywords
Prevalence of relevant NS5A resistance-associated substitutions to elbasvir in genotype 1a hepatitis C virus patients in Spain
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DOI: 10.1016/j.eimce.2017.03.028
Abstract: Abstract Resistance-associated substitutions (RASs) to the new HCV NS5A inhibitor elbasvir may limit its efficacy and lead to virological failure in HCV-GT1a-infected patients. There are no data outside clinical trials evaluating their prevalence and impact… read more here.
Keywords: elbasvir; hcv; rass; prevalence ... See more keywords
Discovery of MK-6169, a Potent Pan-Genotype Hepatitis C Virus NS5A Inhibitor with Optimized Activity against Common Resistance-Associated Substitutions.
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DOI: 10.1021/acs.jmedchem.7b01927
Abstract: We describe the discovery of MK-6169, a potent and pan-genotype hepatitis C virus NS5A inhibitor with optimized activity against common resistance-associated substitutions. SAR studies around the combination of changes to both the valine and aminal… read more here.
Keywords: 6169 potent; associated substitutions; resistance associated; common resistance ... See more keywords
Prevalence of Single and Multiple Natural NS3, NS5A and NS5B Resistance-Associated Substitutions in Hepatitis C Virus Genotypes 1–4 in Italy
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DOI: 10.1038/s41598-018-26862-y
Abstract: Natural resistance-associated substitutions (RASs) are reported with highly variable prevalence across different HCV genotypes (GTs). Frequency of natural RASs in a large Italian real-life cohort of patients infected with the 4 main HCV-GTs was investigated.… read more here.
Keywords: ns3 ns5a; rass; prevalence; associated substitutions ... See more keywords
Hepatitis C Resistance-Associated Substitutions Among People Who Inject Drugs Treated With Direct-Acting Antiviral-Containing Regimens
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DOI: 10.1093/ofid/ofab474
Abstract: Abstract Background Resistance-associated substitutions (RASs) to HCV direct-acting antivirals (DAAs) can contribute to virologic failure and limit retreatment options. People who inject drugs (PWID) are at highest risk for transmission of resistant virus. We report… read more here.
Keywords: inject drugs; rass; direct acting; associated substitutions ... See more keywords
Analysis of Hepatitis C Virus Resistance-Associated Substitutions in Direct-Acting Antiviral Failure in South Korea Using Next-Generation Sequencing.
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DOI: 10.3350/cmh.2022.0345
Abstract: Background/Aims We analyzed resistance-associated substitutions (RAS) and retreatment outcomes in patients with chronic hepatitis C virus (HCV) infection who failed direct-acting antiviral agent (DAA) treatment in South Korea using next-generation sequencing (NGS). Methods Using prospectively… read more here.
Keywords: korea; genotype; failure; associated substitutions ... See more keywords
Baseline and Post-Treatment Hepatitis C NS5A Resistance in Relapsed Patients from a Multicentric Real-Life Cohort
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DOI: 10.3851/imp3184
Abstract: Background Recent data have suggested that failure to achieve sustained virological response with direct-acting antiviral therapy is usually due to relapse and is primarily associated with the emergence of resistance-associated substitutions. The aim of this… read more here.
Keywords: treatment; non structural; associated substitutions; resistance ... See more keywords