The Frequency of Common Deafness-Associated Variants Among 3,555,336 Newborns in China and 141,456 Individuals Across Seven Populations Worldwide
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DOI: 10.1097/aud.0000000000001274
Abstract: Objectives: Genetic screening can benefit early detection and intervention for hearing loss. The frequency of common deafness-associated variants in general populations is highly important for genetic screening and genetic counseling tailored to different ethnic backgrounds.… read more here.
Keywords: common deafness; associated variants; deafness associated; population ... See more keywords
Ultra‐deep sequencing analysis of resistance‐associated variants during retreatment with simeprevir‐based triple therapy after failure of telaprevir‐based triple therapy in patients with genotype 1 hepatitis C virus infection
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DOI: 10.1111/hepr.12817
Abstract: Simeprevir (SMV)‐based triple therapy is an effective retreatment option following failure of telaprevir (TVR)‐based triple therapy. However, it is unclear whether the persistence of resistance‐associated variants (RAVs) induced by TVR‐based therapy may reduce the treatment… read more here.
Keywords: based triple; triple therapy; associated variants; failure telaprevir ... See more keywords
Effects of Coronary Artery Disease–Associated Variants on Vascular Smooth Muscle Cells
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DOI: 10.1161/circulationaha.121.058389
Abstract: Background: Genome-wide association studies have identified many genetic loci that are robustly associated with coronary artery disease (CAD). However, the underlying biological mechanisms are still unknown for most of these loci, hindering the progress to… read more here.
Keywords: trait locus; quantitative trait; associated variants; cad ... See more keywords
Real-life prevalence of resistance-associated variants against non-structural protein 5A inhibitors and efficiency of Daclatasvir + Asunaprevir therapy in Korean patients with genotype 1b hepatitis C
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DOI: 10.1186/s12985-017-0826-1
Abstract: BackgroundDirect-acting antivirals (DAAs) for chronic hepatitis C (CHC) treatment are tolerable and highly effective in a shorter period of time than before. However, resistance-associated variants (RAVs) can affect the efficacy of DAAs. The aim of… read more here.
Keywords: hepatitis; treatment; patients genotype; associated variants ... See more keywords