Liver Directed Adeno-Associated Viral Vectors to Treat Metabolic Disease.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of inherited metabolic disease"
DOI: 10.1002/jimd.12637
Abstract: The liver is the metabolic center of the body and an ideal target for gene therapy of inherited metabolic disorders (IMDs). Adeno-associated viral (AAV) vectors can deliver transgenes to the liver with high efficiency and… read more here.
Keywords: adeno associated; gene therapy; metabolic disease; liver directed ... See more keywords
Mitochondrial changes associated with viral infectious diseases in the paediatric population.
Sign Up to like & getrecommendations! Published in 2021 at "Reviews in medical virology"
DOI: 10.1002/rmv.2232
Abstract: Infectious diseases occur worldwide with great frequency in both adults and children, causing 350,000 deaths in 2017, according to the latest World Health Organization reports. Both infections and their treatments trigger mitochondrial interactions at multiple… read more here.
Keywords: infectious diseases; viral infectious; associated viral; changes associated ... See more keywords
Scalable Production and Purification of Adeno-Associated Viral Vectors (AAV).
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8730-6_17
Abstract: Here we describe methods for the production of adeno-associated viral (AAV) vectors by transient transfection of HEK293 cells grown in serum-free medium in orbital shaken bioreactors and the subsequent purification of vector particles. The protocol… read more here.
Keywords: scalable production; production; associated viral; adeno associated ... See more keywords
Stability and Dissociation of Adeno-Associated Viral Capsids by Variable Temperature-Charge Detection-Mass Spectrometry.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c02378
Abstract: Adeno-associated viral (AAV) vectors have emerged as gene therapy and vaccine delivery systems. Differential scanning fluorimetry or differential scanning calorimetry is commonly used to measure the thermal stability of AAVs, but these global methods are… read more here.
Keywords: detection mass; associated viral; mass spectrometry; adeno associated ... See more keywords
In vivo genetic manipulation of inner ear connexin expression by bovine adeno-associated viral vectors
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-06759-y
Abstract: We have previously shown that in vitro transduction with bovine adeno–associated viral (BAAV) vectors restores connexin expression and rescues gap junction coupling in cochlear organotypic cultures from connexin–deficient mice that are models DFNB1 nonsyndromic hearing… read more here.
Keywords: bovine adeno; associated viral; adeno associated; expression ... See more keywords
Ex vivo Gene Delivery to Porcine Cardiac Allografts using a Myocardial-enhanced Adeno-associated Viral Vector.
Sign Up to like & getrecommendations! Published in 2023 at "Human gene therapy"
DOI: 10.1089/hum.2022.241
Abstract: Transplantation, the gold standard intervention for organ failure, is a clinical field that is ripe for applications of gene therapy. One of the major challenges in applying gene therapy to this field is the need… read more here.
Keywords: adeno associated; gene therapy; associated viral; gene delivery ... See more keywords
Adenovirus Remodeling of the Host Proteome and Host Factors Associated with Viral Genomes
Sign Up to like & getrecommendations! Published in 2021 at "mSystems"
DOI: 10.1128/msystems.00468-21
Abstract: Viral infections induce myriad changes to the host cell proteome. As viruses harness cellular processes and counteract host defenses, they impact abundance, posttranslational modifications, interactions, or localization of cellular proteins. ABSTRACT Viral infections are associated… read more here.
Keywords: viral genomes; infection; associated viral; host ... See more keywords
Immunotherapy for transplantation-associated viral infections
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Investigation"
DOI: 10.1172/jci90599
Abstract: Cytomegalovirus (CMV) and Epstein-Barr virus (EBV) infections following allogeneic hematopoietic stem cell transplantation (HSCT) are a major cause of morbidity and mortality. Early clinical trials demonstrate that adoptive transfer of donor-derived virus-specific T cells to… read more here.
Keywords: immunotherapy transplantation; associated viral; transplantation associated; virus specific ... See more keywords
252-LB: Insulin Secretion Pathway Genes Correlate with Markers Associated with Viral Infections in Human Islets
Sign Up to like & getrecommendations! Published in 2020 at "Diabetes"
DOI: 10.2337/db20-252-lb
Abstract: Type 1 diabetes (T1D) is an autoimmune disease hypothesized, to be enhanced or triggered by viral infections. In this study we used organ donor pancreas to isolate islets that expressed known signs of viral infections,… read more here.
Keywords: insulin secretion; viral infections; associated viral; secretion pathway ... See more keywords
Adeno-Associated Viral Vectors as a Tool for Large Gene Delivery to the Retina
Sign Up to like & getrecommendations! Published in 2019 at "Genes"
DOI: 10.3390/genes10040287
Abstract: Gene therapy using adeno-associated viral (AAV) vectors currently represents the most promising approach for the treatment of many inherited retinal diseases (IRDs), given AAV’s ability to efficiently deliver therapeutic genes to both photoreceptors and retinal… read more here.
Keywords: viral vectors; vectors tool; associated viral; aav vectors ... See more keywords