A comparison of popular TDT‐generalizations for family‐based association analysis
Sign Up to like & getrecommendations! Published in 2019 at "Genetic Epidemiology"
DOI: 10.1002/gepi.22181
Abstract: The transmission disequilibrium test (TDT) is the gold standard for testing the association between a genetic variant and disease in samples consisting of affected individuals and their parents. In practice, more complex pedigree structures, that… read more here.
Keywords: based association; tdt generalizations; association; generalizations family ... See more keywords
Association analysis of exome variants and refraction, axial length, and corneal curvature in a European–American population
Sign Up to like & getrecommendations! Published in 2018 at "Human Mutation"
DOI: 10.1002/humu.23628
Abstract: Refractive errors, myopia, and hyperopia are common visual disorders greatly affecting older individuals. Refraction is determined by genetic factors but only a small percentage of its variation has been explained. We performed a genetic association… read more here.
Keywords: corneal curvature; association analysis; axial length; refraction axial ... See more keywords
Integrated Genomic Strategies for Cereal Genetic Enhancement: Combining QTL and Association Mapping.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9865-4_3
Abstract: Identification of genetic basis for important agronomic traits is essential for marker-assisted crop improvement. Linkage mapping is one of the most popular approaches utilized for identification of major quantitative trait loci (QTLs) governing important agronomic… read more here.
Keywords: association analysis; genetic enhancement; association; association mapping ... See more keywords
A Genome-wide Expression Association Analysis Identifies Genes and Pathways Associated with Amyotrophic Lateral Sclerosis
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-017-0512-2
Abstract: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with strong genetic components. To identity novel risk variants for ALS, utilizing the latest genome-wide association studies (GWAS) and eQTL study data, we conducted a genome-wide expression… read more here.
Keywords: genome wide; analysis; value; expression association ... See more keywords
Goat CTNNB1: mRNA expression profile of alternative splicing in testis and association analysis with litter size.
Sign Up to like & getrecommendations! Published in 2018 at "Gene"
DOI: 10.1016/j.gene.2018.08.061
Abstract: Catenin beta 1 (CTNNB1, also known as β-catenin), is a key gene involved in wnt-β-catenin signaling pathway and plays a significant role in animal reproduction. The aim of this study was to explore the expression… read more here.
Keywords: testis; litter size; expression; association analysis ... See more keywords
Association analysis of DNA methyltransferases in IgA nephropathy.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2019.106147
Abstract: DNA methylation, especially DNA methyltransferases (DNMTs), is involved in the pathogenesis of many autoimmune diseases through regulating immune function. This study aimed to explore the potential role of DNMTs in IgA nephropathy (IgAN). We evaluated… read more here.
Keywords: igan patients; association analysis; iga nephropathy; dna methyltransferases ... See more keywords
Resequencing and association analysis of GAP43 with autism spectrum disorder and schizophrenia in a Japanese population
Sign Up to like & getrecommendations! Published in 2021 at "Research in Autism Spectrum Disorders"
DOI: 10.1016/j.rasd.2021.101729
Abstract: Abstract Background Growth-associated protein 43 (GAP43), a synaptic protein involved in axonal growth and synaptic plasticity, is implicated in the pathophysiology of autism spectrum disorder (ASD) and schizophrenia. To examine the role of rare GAP43… read more here.
Keywords: japanese population; association analysis; autism spectrum; gap43 ... See more keywords
Non-additive association analysis using proxy phenotypes identifies novel cattle syndromes.
Sign Up to like & getrecommendations! Published in 2021 at "Nature genetics"
DOI: 10.1038/s41588-021-00872-5
Abstract: Mammalian species carry ~100 loss-of-function variants per individual1,2, where ~1-5 of these impact essential genes and cause embryonic lethality or severe disease when homozygous3. The functions of the remainder are more difficult to resolve, although… read more here.
Keywords: using proxy; additive association; association; association analysis ... See more keywords
Association analysis of molecular markers with traits under drought stress in safflower
Sign Up to like & getrecommendations! Published in 2017 at "Crop and Pasture Science"
DOI: 10.1071/cp16252
Abstract: Abstract. This study was performed to identify marker loci associated with important agronomic traits and oil content under two moisture conditions and find stable associations in test environments in a worldwide collection of safflower (Carthamus… read more here.
Keywords: drought stress; seed; association analysis;
Association analysis of indels in the VISFATIN gene with five cattle breeds and their growth traits.
Sign Up to like & getrecommendations! Published in 2022 at "Animal biotechnology"
DOI: 10.1080/10495398.2022.2094801
Abstract: VISFATIN is an adipose cytokine that has been proved to correlate with growth and development traits. In a previous study from our lab, two insertion/deletions (indels; including a 35-bp insertion at its intron 4 and… read more here.
Keywords: growth; visfatin gene; association analysis; growth traits ... See more keywords
IMIX: a multivariate mixture model approach to association analysis through multi-omics data integration
Sign Up to like & getrecommendations! Published in 2021 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btaa1001
Abstract: MOTIVATION Integrative genomic analysis is a powerful tool used to study the biological mechanisms underlying a complex disease or trait across multiplatform high-dimensional data, such as DNA methylation, copy number variation, and gene expression. It… read more here.
Keywords: fdr; analysis; association analysis; model ... See more keywords