Association of SMAD4 loss with response to neoadjuvant chemotherapy with the autophagy inhibitor hydroxychloroquine in patients with pancreatic adenocarcinoma.
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DOI: 10.1200/jco.2020.38.4_suppl.761
Abstract: 761Background: SMAD4, a tumor suppressor gene, is inactivated or deleted in 60-90% of pancreatic adenocarcinomas (PDA). Loss of SMAD4 allows tumor progression by limiting cell cycle arrest and apop... read more here.
Keywords: response neoadjuvant; loss response; smad4 loss; neoadjuvant chemotherapy ... See more keywords