Genome‐wide association studies reveal shared genetic haplotypes of autoimmune rheumatic and endocrine diseases with psychiatric disorders
Sign Up to like & getrecommendations! Published in 2023 at "Brain and Behavior"
DOI: 10.1002/brb3.2955
Abstract: Several studies have shown that autoimmune diseases are associated with psychiatric diseases like depression and psychosis. Genetic evidence supports this association. The aim of this study was to investigate if genetic variants predisposing to autoimmune… read more here.
Keywords: psychiatric disorders; genome wide; wide association; diseases psychiatric ... See more keywords
DrugWAS: Drug‐wide Association Studies for COVID‐19 Drug Repurposing
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.2376
Abstract: This study aimed to systematically investigate if any of the available drugs in the electronic health record (EHR) can be repurposed as potential treatment for coronavirus disease 2019 (COVID‐19). Based on a retrospective cohort analysis… read more here.
Keywords: association studies; drug wide; drug; covid ... See more keywords
Joint genotype‐ and ancestry‐based genome‐wide association studies in admixed populations
Sign Up to like & getrecommendations! Published in 2017 at "Genetic Epidemiology"
DOI: 10.1002/gepi.22056
Abstract: In genome‐wide association studies (GWAS) genetic loci that influence complex traits are localized by inspecting associations between genotypes of genetic markers and the values of the trait of interest. On the other hand, admixture mapping,… read more here.
Keywords: genome wide; association studies; genotype ancestry; ancestry ... See more keywords
Estimation of a significance threshold for epigenome‐wide association studies
Sign Up to like & getrecommendations! Published in 2018 at "Genetic Epidemiology"
DOI: 10.1002/gepi.22086
Abstract: Epigenome‐wide association studies (EWAS) are designed to characterise population‐level epigenetic differences across the genome and link them to disease. Most commonly, they assess DNA‐methylation status at cytosine‐guanine dinucleotide (CpG) sites, using platforms such as the… read more here.
Keywords: association studies; significance threshold; significance; epigenome wide ... See more keywords
Adjusting for collider bias in genetic association studies using instrumental variable methods
Sign Up to like & getrecommendations! Published in 2022 at "Genetic Epidemiology"
DOI: 10.1002/gepi.22455
Abstract: Genome‐wide association studies have provided many genetic markers that can be used as instrumental variables to adjust for confounding in epidemiological studies. Recently, the principle has been applied to other forms of bias in observational… read more here.
Keywords: bias; instrumental variable; collider bias; variable methods ... See more keywords
Control for population stratification in genetic association studies based on GWAS summary statistics
Sign Up to like & getrecommendations! Published in 2022 at "Genetic Epidemiology"
DOI: 10.1002/gepi.22493
Abstract: Over the past years, genome‐wide association studies (GWAS) have generated a wealth of new information. Summary data from many GWAS are now publicly available, promoting the development of many statistical methods for association studies based… read more here.
Keywords: population; control population; population stratification; association studies ... See more keywords
Phylogenetic Methods for Genome-Wide Association Studies in Bacteria.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1099-2_13
Abstract: Genome-wide association studies in bacteria have great potential to deliver a better understanding of the genetic basis of many biologically important phenotypes, including antibiotic resistance, pathogenicity, and host adaptation. Such studies need however to account… read more here.
Keywords: genome wide; association studies; phylogenetic methods; studies bacteria ... See more keywords
Genome-wide association studies: assessing trait characteristics in model and crop plants
Sign Up to like & getrecommendations! Published in 2021 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-021-03868-w
Abstract: GWAS involves testing genetic variants across the genomes of many individuals of a population to identify genotype–phenotype association. It was initially developed and has proven highly successful in human disease genetics. In plants genome-wide association… read more here.
Keywords: genome wide; association studies; model crop; association ... See more keywords
Advances in genome-wide association studies of complex traits in rice
Sign Up to like & getrecommendations! Published in 2019 at "Theoretical and Applied Genetics"
DOI: 10.1007/s00122-019-03473-3
Abstract: Genome-wide association studies (GWAS), genetic surveys of the whole genome to detect variants associated with a trait in natural populations, are a powerful approach for dissecting complex traits. This genetic mapping approach has been applied… read more here.
Keywords: genome wide; association studies; rice; complex traits ... See more keywords
Associations of osteoprotegerin (OPG) TNFRSF11B gene polymorphisms with risk of fractures in older adult populations: meta-analysis of genetic and genome-wide association studies
Sign Up to like & getrecommendations! Published in 2021 at "Osteoporosis International"
DOI: 10.1007/s00198-021-06161-5
Abstract: The meta-analysis of osteoprotegerin (OPG) (TNFRSF11B) polymorphisms from genetic association studies and genome-wide association studies was performed in order to test the hypothesis of association between OPG polymorphisms and fracture. The findings showed a significant… read more here.
Keywords: association studies; analysis; opg tnfrsf11b; osteoprotegerin opg ... See more keywords
Hearing loss and tinnitus: association studies for complex-hearing disorders in mouse and man.
Sign Up to like & getrecommendations! Published in 2021 at "Human genetics"
DOI: 10.1007/s00439-021-02317-9
Abstract: Genome-wide association studies (GWAS) provide an unbiased first look at genetic loci involved in aging and noise-induced sensorineural hearing loss and tinnitus. The hearing phenotype, whether audiogram-based or self-report, is regressed against genotyped information at… read more here.
Keywords: loss tinnitus; hearing loss; association studies;