Association of OPRM1 Functional Coding Variant With Opioid Use Disorder: A Genome-Wide Association Study.
Sign Up to like & getrecommendations! Published in 2020 at "JAMA psychiatry"
DOI: 10.1001/jamapsychiatry.2020.1206
Abstract: Importance With the current opioid crisis, it is important to improve understanding of the biological mechanisms of opioid use disorder (OUD). Objectives To detect genetic risk variants for OUD and determine genetic correlations and causal… read more here.
Keywords: genome wide; association; association study; american individuals ... See more keywords
Management of Hepatocellular Carcinoma: A Review.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA surgery"
DOI: 10.1001/jamasurg.2022.7989
Abstract: Importance Hepatocellular carcinoma (HCC) is the sixth most common malignancy and fourth leading cause of cancer-related death worldwide. Recent advances in systemic and locoregional therapies have led to changes in many guidelines regarding systemic therapy,… read more here.
Keywords: hepatocellular carcinoma; review; disease; association study ... See more keywords
Genome‐Wide 3′‐UTR Single Nucleotide Polymorphism Association Study Identifies Significant Prostate Cancer Risk‐Associated Functional Loci at 8p21.2 in Chinese Population
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202201420
Abstract: MicroRNAs (miRNAs) are involved in the regulation of gene expression via incomplete base pairing to sequence motifs at the three prime untranslated regions (3′‐UTRs) of mRNAs and play critical roles in the etiology of cancers.… read more here.
Keywords: prostate cancer; genome wide; association study; single nucleotide ... See more keywords
Transcriptome‐wide association study identifies multiple genes and pathways associated with pancreatic cancer
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DOI: 10.1002/cam4.1836
Abstract: To identify novel candidate genes for pancreatic cancer. read more here.
Keywords: study identifies; pancreatic cancer; transcriptome wide; cancer ... See more keywords
Laboratory‐wide association study of survival with prostate cancer
Sign Up to like & getrecommendations! Published in 2020 at "Cancer"
DOI: 10.1002/cncr.33341
Abstract: Estimates of overall patient health are essential to inform treatment decisions for patients diagnosed with cancer. The authors applied XWAS methods, herein referred to as “laboratory‐wide association study (LWAS)”, to evaluate associations between routinely collected… read more here.
Keywords: prostate cancer; cancer; association study; laboratory wide ... See more keywords
Anastrozole Aromatase Inhibitor Plasma Drug Concentration Genome‐Wide Association Study: Functional Epistatic Interaction Between SLC38A7 and ALPPL2
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.1359
Abstract: Anastrozole is a widely prescribed aromatase inhibitor for the therapy of estrogen receptor positive (ER+) breast cancer. We performed a genome‐wide association study (GWAS) for plasma anastrozole concentrations in 687 postmenopausal women with ER+ breast… read more here.
Keywords: genome wide; slc38a7; aromatase inhibitor; epistatic interaction ... See more keywords
Genomewide Association Study of Statin‐Induced Myopathy in Patients Recruited Using the UK Clinical Practice Research Datalink
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.1557
Abstract: Statins can be associated with myopathy. We have undertaken a genomewide association study (GWAS) to discover and validate genetic risk factors for statin‐induced myopathy in a “real‐world” setting. One hundred thirty‐five patients with statin myopathy… read more here.
Keywords: clinical practice; statin induced; association; genomewide association ... See more keywords
Association study between HTR2A rs6313 polymorphism and early response to risperidone and olanzapine in schizophrenia patients
Sign Up to like & getrecommendations! Published in 2020 at "Drug Development Research"
DOI: 10.1002/ddr.21686
Abstract: Antipsychotic drugs are the preferred choice for schizophrenia treatment; however, response is highly variable. In the context of the search for predictors of antipsychotic treatment effectiveness, the evaluation of response within 2 weeks has been indicated… read more here.
Keywords: response; association; schizophrenia patients; risperidone ... See more keywords
Primary Biliary Cholangitis: 2018 Practice Guidance from the American Association for the Study of Liver Diseases
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology"
DOI: 10.1002/hep.30145
Abstract: This American Association for the Study of Liver Diseases (AASLD) 2018 Practice Guidance on Primary Biliary Cholangitis (PBC) is an update of the PBC guidelines published in 2009. The 2018 updated guidance on PBC includes… read more here.
Keywords: pbc; american association; guidance; practice ... See more keywords
Genome-wide association study of liver-related enzymes suggests putative pleiotropic effects on diverse traits and diseases.
Sign Up to like & getrecommendations! Published in 2021 at "Hepatology"
DOI: 10.1002/hep.32175
Abstract: Over the last decade, genome-wide association studies (GWAS) have allowed for the dissection of the genetic susceptibility to complex liver diseases.1 In a recent issue of Nature communications, Chen and colleagues conducted a meta-analysis of… read more here.
Keywords: liver related; genome wide; related enzymes; association study ... See more keywords
Genomewide association study of Parkinson's disease clinical biomarkers in 12 longitudinal patients' cohorts
Sign Up to like & getrecommendations! Published in 2019 at "Movement Disorders"
DOI: 10.1002/mds.27845
Abstract: Several reports have identified different patterns of Parkinson's disease progression in individuals carrying missense variants in GBA or LRRK2 genes. The overall contribution of genetic factors to the severity and progression of Parkinson's disease, however,… read more here.
Keywords: disease; genomewide association; parkinson disease; association study ... See more keywords