Rare variant association testing for multicategory phenotype
Sign Up to like & getrecommendations! Published in 2019 at "Genetic Epidemiology"
DOI: 10.1002/gepi.22210
Abstract: Genetic association studies have provided new insights into the genetic variability of human complex traits with a focus mainly on continuous or binary traits. Methods have been proposed to take into account disease heterogeneity between… read more here.
Keywords: association testing; association; burden tests; rare variants ... See more keywords
Powerful and Efficient Strategies for Genetic Association Testing of Symptom and Questionnaire Data in Psychiatric Genetic Studies
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-44046-0
Abstract: Genetic studies of psychiatric disorders often deal with phenotypes that are not directly measurable. Instead, researchers rely on multivariate symptom data from questionnaires and surveys like the PTSD Symptom Scale (PSS) and Beck Depression Inventory… read more here.
Keywords: association testing; genetic association; questionnaire data; symptom ... See more keywords
LDAK-GBAT: fast and powerful gene-based association testing using summary statistics
Sign Up to like & getrecommendations! Published in 2022 at "American journal of human genetics"
DOI: 10.1101/2022.07.01.22277161
Abstract: We present LDAK-GBAT, a novel tool for gene-based association testing using summary statistics from genome-wide association studies. We first evaluate LDAK-GBAT using ten phenotypes from the UK Biobank. We show that LDAK-GBAT is computationally efficient,… read more here.
Keywords: based association; association testing; gbat; gene based ... See more keywords