Construction of a Multiple-aptamer-based DNA Logic Device on Live Cell Membranes via Associative Toehold Activation for Accurate Cancer Cell Identification.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b05470
Abstract: The ability to accurately identify and isolate cells is the cornerstone of precise disease diagnosis and therapies. A single-step cell identification method based on logic analysis of multiple surface markers will have unique advantages because… read more here.
Keywords: toehold activation; cell identification; associative toehold; cancer ... See more keywords
Dynamically elongated associative toehold for tuning DNA circuit kinetics and thermodynamics
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab212
Abstract: Abstract Associative toehold is a powerful concept enabling efficient combinatorial computation in DNA circuit. A longer association length boosts circuit kinetics and equilibrium signal but results in higher leak rate. We reconcile this trade-off by… read more here.
Keywords: dna circuit; thermodynamics; associative toehold; toehold ... See more keywords