Proportional odds assumption for modeling longitudinal ordinal multiple toxicity outcomes in dose finding studies of targeted agents: A pooled analysis of 54 studies
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DOI: 10.1016/j.conctc.2020.100529
Abstract: Background Data generated by phase I trials is richer than the classical binary DLT measured at the first cycle used as primary endpoints. Several works developed designs for more informative endpoints, e.g. ordinal toxicity grades… read more here.
Keywords: proportional odds; odds assumption; assumption; assumption modeling ... See more keywords