AST-120 Treatment Alters the Gut Microbiota Composition and Suppresses Hepatic Triglyceride Levels in Obese Mice
Sign Up to like & getrecommendations! Published in 2021 at "Endocrine Research"
DOI: 10.1080/07435800.2021.1927074
Abstract: ABSTRACT Background: The prevalence of nonalcoholic fatty liver disease (NAFLD) has been increasing worldwide. The existence of a relationship between the microbiota and the pathology of hepatic steatosis is also becoming increasingly clear. AST-120, an… read more here.
Keywords: hepatic triglyceride; triglyceride levels; 120 treatment; gut microbiota ... See more keywords
Review of the efficacy of AST-120 (KREMEZIN®) on renal function in chronic kidney disease patients
Sign Up to like & getrecommendations! Published in 2019 at "Renal Failure"
DOI: 10.1080/0886022x.2018.1561376
Abstract: Abstract AST-120 (KREMEZIN®) consists of oral, spherical carbon particles that adsorb uremic toxins and their precursors within the gastrointestinal tract, allowing them to be excreted in the feces. Uremic toxins such as indoxyl sulfate and… read more here.
Keywords: 120 kremezin; chronic kidney; ast 120; ckd ... See more keywords
AST-120 Improves Cardiac Dysfunction in Acute Kidney Injury Mice via Suppression of Apoptosis and Proinflammatory NF-κB/ICAM-1 Signaling
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DOI: 10.2147/jir.s283378
Abstract: Purpose Acute kidney injury (AKI) is a devastating disorder associated with considerably high morbidity and mortality. Reports have shown that AST-120, an oral charcoal adsorbent, can reduce oxidative stress by lowering serum indoxyl sulfate levels.… read more here.
Keywords: kidney injury; indoxyl sulfate; ast 120; cardiac dysfunction ... See more keywords
The role of carbon adsorbent in the conservative management of chronic kidney disease.
Sign Up to like & getrecommendations! Published in 2017 at "Panminerva medica"
DOI: 10.23736/s0031-0808.16.03272-9
Abstract: Indoxyl sulfate is a uremic toxin, and cannot be removed efficiently by hemodialysis due to its protein-binding. Indoxyl sulfate induces cellular dysfunction by producing reactive oxygen species (ROS) such as superoxide by activating nicotinamide adenine… read more here.
Keywords: chronic kidney; indoxyl sulfate; ckd; ast 120 ... See more keywords