Performance improvement of Compton imaging of astatine-211 by optimising coincidence time windows
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Instrumentation"
DOI: 10.1088/1748-0221/16/12/c12031
Abstract: Astatine-211 is one of the promising radioisotopes for targeted alpha therapy. Optimising treatment strategies as well as determining the suitability of a given agent for a particular patient requires to image the time-dependent distribution of… read more here.
Keywords: astatine 211; coincidence time; coincidence; compton ... See more keywords
Simulation of the distribution of astatine-211 solution dispersion in a lab room
Sign Up to like & getrecommendations! Published in 2021 at "Nuclear Medicine Communications"
DOI: 10.1097/mnm.0000000000001430
Abstract: Objective This study aimed to evaluate the distribution of Astatine-211 (211At) solution dispersion in a small animal cage using autoradiography imaging to simulate the dispersion of 211At in a lab room to eventually prevent user’s… read more here.
Keywords: dispersion; distribution astatine; astatine 211; distribution ... See more keywords
Abstract 4344: Broader therapeutic window via combining sodium ascorbate for protecting radioactive antibodies from radiolysis and sodium perchlorate for blocking sodium iodide symporter in radioimmunotherapy with astatine-211
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-4344
Abstract: Increasing attention has been paid to developing new cancer treatments with alpha particles characterized by a high linear energy transfer (LET) and a range of 50-100 µm in tissue, which is equivalent to 5-10 cells.… read more here.
Keywords: astatine 211; therapeutic window; stomach; accumulation ... See more keywords
Astatine-211 based radionuclide therapy: Current clinical trial landscape
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2022.1076210
Abstract: Astatine-211 (211At) has physical properties that make it one of the top candidates for use as a radiation source for alpha particle-based radionuclide therapy, also referred to as targeted alpha therapy (TAT). Here, we summarize… read more here.
Keywords: 211 based; therapy current; based radionuclide; current clinical ... See more keywords
Astatine-211 and actinium-225: two promising nuclides in targeted alpha therapy
Sign Up to like & getrecommendations! Published in 2024 at "Acta Biochimica et Biophysica Sinica"
DOI: 10.3724/abbs.2024206
Abstract: Nuclear medicine therapy offers a promising approach for tumor treatment, as the energy emitted during radionuclide decay causes irreparable damage to tumor cells. Notably, α-decay exhibits an even more significant destructive potential. By conjugating α-nuclides… read more here.
Keywords: astatine 211; therapy; actinium 225; tumor ... See more keywords