Multistage Antiplasmodium Activity of Astemizole Analogues and Inhibition of Hemozoin Formation as a Contributor to Their Mode of Action.
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DOI: 10.1021/acsinfecdis.8b00272
Abstract: A drug repositioning approach was leveraged to derivatize astemizole (AST), an antihistamine drug whose antimalarial activity was previously identified in a high-throughput screen. The multistage activity potential against the Plasmodium parasite's life cycle of the… read more here.
Keywords: formation; inhibition hemozoin; mode action; astemizole ... See more keywords