Identification of a homozygous GFPT2 variant in a family with asthenozoospermia.
Sign Up to like & getrecommendations! Published in 2019 at "Gene"
DOI: 10.1016/j.gene.2019.02.060
Abstract: PURPOSE Asthenozoospermia (ASZ) is a condition characterized by reduced sperm motility in semen affecting approximately 19% of infertile men. Major risk factors, particularly gene mutations, still remain unknown. The main aim of the present study… read more here.
Keywords: sperm motility; identification homozygous; gfpt2 variant; asthenozoospermia ... See more keywords
Proteomics analysis of asthenozoospermia and identification of glucose-6-phosphate isomerase as an important enzyme for sperm motility.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of proteomics"
DOI: 10.1016/j.jprot.2019.103478
Abstract: Asthenozoospermia, in which sperm motility is affected, is one of the primary causes of male infertility. However, the exact mechanism responsible for the defective motility remains unknown. It is important to identify the precise proteins… read more here.
Keywords: analysis; sperm motility; glucose phosphate; motility ... See more keywords
Expression of NDUFA13 in asthenozoospermia and possible pathogenesis.
Sign Up to like & getrecommendations! Published in 2017 at "Reproductive biomedicine online"
DOI: 10.1016/j.rbmo.2016.10.001
Abstract: Asthenozoospermia is a common cause of male infertility, which is characterized by reduced forward motility of spermatozoa. The cause and pathogenesis of asthenozoospermia are not fully understood. The purpose of this study was to investigate… read more here.
Keywords: expression ndufa13; possible pathogenesis; expression; asthenozoospermia ... See more keywords
Ferritin-Nanocaged ATP Traverses the Blood-Testis Barrier and Enhances Sperm Motility in an Asthenozoospermia Model.
Sign Up to like & getrecommendations! Published in 2022 at "ACS nano"
DOI: 10.1021/acsnano.1c10029
Abstract: Sperm motility can be enhanced by adding ATP exogenously during in vitro fertilization. However, administering exogenous ATP to the testis to improve sperm motility for in vivo asthenozoospermia treatment has not been investigated yet. Inspired… read more here.
Keywords: blood testis; testis barrier; sperm motility; asthenozoospermia ... See more keywords
ADCY10 frameshift variant leading to severe recessive asthenozoospermia and segregating with absorptive hypercalciuria.
Sign Up to like & getrecommendations! Published in 2019 at "Human reproduction"
DOI: 10.1093/humrep/dez048
Abstract: STUDY QUESTION Can whole exome sequencing (WES) reveal a novel pathogenic variant in asthenozoospermia in a multiplex family including multiple patients? SUMMARY ANSWER Patients were discovered to be homozygous for a rare 2-bp deletion in… read more here.
Keywords: absorptive hypercalciuria; variant; study; sperm ... See more keywords
Expression of miR-135a-5p and its target gene JAK2 in spermatozoa of patients with asthenozoospermia.
Sign Up to like & getrecommendations! Published in 2021 at "Andrologia"
DOI: 10.1111/and.14214
Abstract: This study aimed to identify the molecular mechanism by which JAK2 mRNA and microRNA-135a-5p (miR-135a-5p) affect asthenozoospermia. The expression levels of JAK2 mRNA in the spermatozoa of 30 asthenozoospermia patients and 30 normal controls were… read more here.
Keywords: jak2 mrna; asthenozoospermia; mir 135a; expression mir ... See more keywords
Biallelic mutations in ARMC12 cause asthenozoospermia and multiple midpiece defects in humans and mice
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Genetics"
DOI: 10.1136/jmedgenet-2021-108137
Abstract: Background Asthenozoospermia is a major factor contributing to male infertility. The mitochondrial sheath (MS), an important organelle in the midpiece of spermatozoa, is crucial to sperm motility. ARMC12 is a mitochondrial peripheral membrane protein. Deletion… read more here.
Keywords: multiple midpiece; midpiece defects; microscopy; asthenozoospermia ... See more keywords
Identification of hub genes and biological mechanisms underlying the pathogenesis of asthenozoospermia and chronic epididymitis
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2023.1110218
Abstract: Objective: Asthenozoospermia (AZS) is one of the most common causes of male fertility, affecting family wellbeing and population growth. Chronic epididymitis (CE) is a common and lingering inflammatory disease in the scrotum. Inflammation in the… read more here.
Keywords: hub genes; chronic epididymitis; hub; asthenozoospermia ... See more keywords
C-Type Natriuretic Peptide (CNP) Could Improve Sperm Motility and Reproductive Function of Asthenozoospermia
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231810370
Abstract: This study is to analyze the effect of C-type natriuretic peptide (CNP) on sperm motility of asthenozoospermia and explore the influence mechanism of CNP on the reproductive system and sperm motility. Our results showed that… read more here.
Keywords: cnp; natriuretic peptide; type natriuretic; asthenozoospermia ... See more keywords
Associations between Meat and Vegetable Intake, Cooking Methods, and Asthenozoospermia: A Hospital-Based Case–Control Study in China
Sign Up to like & getrecommendations! Published in 2022 at "Nutrients"
DOI: 10.3390/nu14091956
Abstract: Abstract Background: The role of meat and vegetable intake in the development of asthenozoospermia has been controversial, and the role of cooking methods for meat and vegetables in the association has yet to be determined.… read more here.
Keywords: asthenozoospermia; risk; meat vegetable; meat ... See more keywords
DEFB126 polymorphisms and association with idiopathic asthenozoospermia in China
Sign Up to like & getrecommendations! Published in 2022 at "Asian Journal of Andrology"
DOI: 10.4103/aja2021115
Abstract: Idiopathic asthenozoospermia, a common factor in male infertility, is characterized by altered sperm motility function in fresh ejaculate. Although the β-defensin 126 (DEFB126) protein is associated with asthenozoospermia, DEFB126 gene polymorphisms have not been extensively… read more here.
Keywords: defb126 gene; idiopathic asthenozoospermia; defb126; asthenozoospermia ... See more keywords