Application of automated machine learning in the identification of multi-target-directed ligands blocking PDE4B, PDE8A, and TRPA1 with potential use in the treatment of asthma and COPD.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular informatics"
DOI: 10.1002/minf.202200214
Abstract: The aim of the study was to develop AutoML models to search for novel MTDL chemotypes blocking PDE4B, PDE8A, and TRPA1. Asthma and COPD are characterized by complex pathophysiology associated with chronic inflammation, bronchoconstriction, and… read more here.
Keywords: pde4b pde8a; asthma copd; blocking pde4b; pde4b ... See more keywords
Evaluation of New Drugs for Asthma and COPD: Endpoints, Biomarkers and Clinical Trial Design.
Sign Up to like & getrecommendations! Published in 2017 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2016_70
Abstract: There remains a considerable need to develop novel therapies for patients with asthma and chronic obstructive pulmonary disease (COPD). The greatest challenge at the moment is measuring the effects of novel anti-inflammatory drugs, as these… read more here.
Keywords: evaluation new; copd endpoints; asthma copd; copd ... See more keywords
Overview on Interactive Role of Inflammation, Reactive Oxygen Species, and Calcium Signaling in Asthma, COPD, and Pulmonary Hypertension.
Sign Up to like & getrecommendations! Published in 2021 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-68748-9_9
Abstract: Inflammatory signaling is a major component in the development and progression of many lung diseases, including asthma, chronic obstructive pulmonary disorder (COPD), and pulmonary hypertension (PH). This chapter will provide a brief overview of asthma,… read more here.
Keywords: copd pulmonary; inflammation; asthma copd; copd ... See more keywords
Alveolar and Bronchial Nitric Oxide in Chronic Obstructive Pulmonary Disease and Asthma-COPD Overlap.
Sign Up to like & getrecommendations! Published in 2018 at "Archivos De Bronconeumologia"
DOI: 10.1016/j.arbr.2018.06.007
Abstract: Abstract Introduction Exhaled nitric oxide (FENO) measurements differentiate COPD phenotypes from asthma–COPD overlap (ACO). To date, no study has been conducted to determine whether alveolar and bronchial components differ in this group of patients. Methods… read more here.
Keywords: alveolar bronchial; asthma copd; jawno; copd ... See more keywords
Airway diseases and health literacy (HL) measurement tools: A systematic review to inform respiratory research and practice.
Sign Up to like & getrecommendations! Published in 2018 at "Patient education and counseling"
DOI: 10.1016/j.pec.2017.10.011
Abstract: OBJECTIVE To identify and evaluate asthma/COPD measurement tools that assess any of the five health literacy (HL) domains: (1) access, (2) understand, (3) evaluate, (4) communicate, and (5) use, as well as numeracy. METHODS MEDLINE/Embase… read more here.
Keywords: measurement; health literacy; measurement tools; asthma copd ... See more keywords
Work absence in patients with asthma and/or COPD: a population-based study
Sign Up to like & getrecommendations! Published in 2021 at "NPJ Primary Care Respiratory Medicine"
DOI: 10.1038/s41533-021-00217-z
Abstract: Chronic obstructive pulmonary disease (COPD) and asthma impact on work productivity, but their population-based burden and clinical predictors are understudied. In this observational, real-life study, work absence of 14,383 asthma and/or COPD patients present in… read more here.
Keywords: work absence; work; asthma copd; patients asthma ... See more keywords
Physiological and morphological differences of airways between COPD and asthma–COPD overlap
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-44345-6
Abstract: Overlap of asthma and COPD has attracted attention recently. We aimed to clarify physiological and morphological differences of the airways between COPD and asthma–COPD overlap (ACO). Respiratory resistance and reactance and three-dimensional computed tomography data… read more here.
Keywords: morphological differences; asthma copd; differences airways; asthma ... See more keywords
Effects of PM10 on mortality in pure COPD and asthma-COPD overlap: difference in exposure duration, gender, and smoking status
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-59246-2
Abstract: We investigated the effects of particulate matter (PM) on mortality in patients diagnosed with asthma-COPD overlap (ACO) or ‘pure COPD’. Subjects from the National Health Insurance Service–National Sample Cohort of Korea, who were aged 40… read more here.
Keywords: exposure; pure copd; asthma copd; copd ... See more keywords
The relationship between objective app engagement and medication adherence in asthma and COPD: a retrospective analysis
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-03827-2
Abstract: Digital health tools can promote disease self-management, but the association of smartphone app engagement and medication adherence is unclear. We assessed the relationship between objective smartphone app engagement and controller medication use in adults with… read more here.
Keywords: asthma copd; relationship; app engagement; medication ... See more keywords
[Reduction of greenhouse gas emissions by inhaler choice in the therapy of asthma and COPD patients].
Sign Up to like & getrecommendations! Published in 2022 at "Pneumologie"
DOI: 10.1055/a-1771-5292
Abstract: BACKGROUND The global warming potential of inhaled medication depends on the applied inhaler. Pressurised metered dose inhalers (pMDI) contain green-house gases (GHG) and are associated with a 10 to 40 times higher CO2-footprint than GHG-free… read more here.
Keywords: therapy; co2 footprint; dpi; inhaler ... See more keywords
Anti-IgE therapy as novel target for asthma-COPD overlap syndrome: More questions before celebration
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Asthma"
DOI: 10.1080/02770903.2016.1201838
Abstract: We read the pioneer work by Tat and colleagues [1] with great interest. The authors reviewed their experience of treating asthma-COPD overlap syndrome (ACOS) patients with the anti-IgE monoclonal antibody, Omalizumab. Treatment with Omalizumab resulted… read more here.
Keywords: overlap syndrome; study; asthma copd; copd overlap ... See more keywords