External validation of the Predicting Asthma Risk in Children tool in a clinical cohort
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DOI: 10.1002/ppul.26088
Abstract: The Predicting Asthma Risk in Children (PARC) tool uses questionnaire‐based respiratory symptoms collected from preschool children to predict asthma risk 5 years later. The tool was developed and validated in population cohorts but not validated… read more here.
Keywords: clinical cohort; risk children; asthma; predicting asthma ... See more keywords
Mother’s education and offspring asthma risk in 10 European cohort studies
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Epidemiology"
DOI: 10.1007/s10654-017-0309-0
Abstract: Highly prevalent and typically beginning in childhood, asthma is a burdensome disease, yet the risk factors for this condition are not clarified. To enhance understanding, this study assessed the cohort-specific and pooled risk of maternal… read more here.
Keywords: risk; asthma risk; cohort; education ... See more keywords
A whole genome sequencing study of moderate to severe asthma identifies a lung function locus associated with asthma risk
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-09447-8
Abstract: Genome-wide association studies (GWAS) have identified many common variant loci associated with asthma susceptibility, but few studies investigate the genetics underlying moderate-to-severe asthma risk. Here, we present a whole-genome sequencing study comparing 3181 moderate-to-severe asthma… read more here.
Keywords: severe asthma; moderate severe; asthma; lung function ... See more keywords
NAT1 genetic variation increases asthma risk in children with secondhand smoke exposure
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Asthma"
DOI: 10.1080/02770903.2019.1694941
Abstract: Abstract Objective We previously reported that children exposed to secondhand smoke (SHS) that carried variants in the NAT1 gene had over two-fold higher hair cotinine levels. Our objective was to determine if NAT1 polymorphisms confer… read more here.
Keywords: risk; asthma risk; secondhand smoke; smoke exposure ... See more keywords
Association of polymorphisms in TLR2 and TLR4 with asthma risk
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DOI: 10.1097/md.0000000000007909
Abstract: Background: Several epidemiological studies have focused on the association between polymorphisms in toll-like receptors (TLRs) and asthma. However, the results remained inconclusive. Methods: We systematically reviewed the database of PubMed, EMBASE, Web of Science, CNKI,… read more here.
Keywords: asthma; asthma risk; associated asthma; association polymorphisms ... See more keywords
From bronchiolitis endotyping to asthma risk assessment
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DOI: 10.1136/thorax-2022-219388
Abstract: Bronchiolitis is the most common lower respiratory tract infection in young children, and it is associated with significant morbidity and high rate of hospitalisa-tion. 1 In addition, epidemiological data show that bronchiolitis during early life… read more here.
Keywords: bronchiolitis; endotyping asthma; bronchiolitis endotyping; risk assessment ... See more keywords
A whole genome sequencing association study of severe, uncontrolled asthma
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DOI: 10.1183/13993003.congress-2018.oa2194
Abstract: Introduction: Genome-wide association studies (GWAS) have discovered >30 loci associated with asthma risk. Despite the characterization of asthma as a heterogeneous disorder, most GWAS evaluate asthmatics as a single population. To explore whether genetics are… read more here.
Keywords: association; risk; asthma risk; whole genome ... See more keywords
Association between ADAM33 polymorphisms and asthma risk: a systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2019 at "Respiratory Research"
DOI: 10.1186/s12931-019-1006-1
Abstract: BackgroundAsthma is a common complex chronic, inflammatory polygenic disease with heterogeneous manifestations, affecting individuals of all age groups and posing an immense burden on healthcare resources. A number of studies have identified the association between… read more here.
Keywords: asthma risk; polymorphisms asthma; analysis; association ... See more keywords
Significant Association of Chitinase 3-like 1 Genotypes to Asthma Risk in Taiwan
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DOI: 10.21873/invivo.12320
Abstract: Background/Aim: Chitinase 3-like 1 (CHI3L1) is overexpressed in asthma, and negatively associated with forced expiratory volume in the first second. This study aimed at evaluating whether CHI3L1 genotypes affect asthma risk. Materials and Methods: The… read more here.
Keywords: chitinase like; chi3l1 131c; risk; asthma risk ... See more keywords
Heterogeneity of asthma and the risk of celiac disease in children.
Sign Up to like & getrecommendations! Published in 2018 at "Allergy and asthma proceedings"
DOI: 10.2500/aap.2018.39.4100
Abstract: BACKGROUND Although human leukocyte antigen (HLA)-DR and HLA-DQ genes and gluten play crucial roles in developing celiac disease (CD), most patients with these risk factors still do not develop CD, which indicates additional unrecognized risk… read more here.
Keywords: risk; asthma risk; celiac disease; heterogeneity asthma ... See more keywords
Genetic liability to asthma and risk of cardiovascular diseases: A Mendelian randomization study
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.879468
Abstract: Background and Aims: Epidemiological studies have suggested positive associations between asthma and the risk of cardiovascular diseases (CVDs). However, causality remains inconclusive. We aim to explore the causal associations between asthma and CVDs risk using… read more here.
Keywords: risk cardiovascular; mendelian randomization; cardiovascular diseases; risk ... See more keywords