Glucocorticosteroids administration is associated with increased regulatory T cells in equine asthmatic lungs.
Sign Up to like & getrecommendations! Published in 2018 at "Veterinary immunology and immunopathology"
DOI: 10.1016/j.vetimm.2018.05.010
Abstract: Recurrent inflammation in severe equine asthma causes a remodeling of the airways leading to incompletely reversible airway obstruction. Despite the improvement of clinical signs and lung function with glucocorticoids (GC), inflammation, translated by an increased… read more here.
Keywords: treg; glucocorticosteroids administration; administration associated; regulatory cells ... See more keywords
Randomised study of the immunomodulatory effects of azithromycin in severely asthmatic horses
Sign Up to like & getrecommendations! Published in 2019 at "Veterinary Record"
DOI: 10.1136/vr.105260
Abstract: Neutrophilic inflammation is believed to contribute to the airway obstruction and remodelling in equine asthma. Azithromycin, an antibiotic with immunomodulatory properties, reduces pulmonary neutrophilia and hyper-responsiveness in human asthmatics and decreases airway remodelling in rodent… read more here.
Keywords: study immunomodulatory; equine asthma; immunomodulatory effects; effects azithromycin ... See more keywords
Neutrophil extracellular traps are downregulated by glucocorticosteroids in lungs in an equine model of asthma
Sign Up to like & getrecommendations! Published in 2017 at "Respiratory Research"
DOI: 10.1186/s12931-017-0689-4
Abstract: BackgroundSevere neutrophilic asthma is poorly responsive to glucocorticosteroids (GC). Neutrophil extracellular traps (NETs) within the lungs have been associated with the severity of airway obstruction and inflammation in asthma, and were found to be unaffected… read more here.
Keywords: neutrophil extracellular; nets formation; traps downregulated; asthma ... See more keywords
Neutrophil Extracellular Traps Are Found in Bronchoalveolar Lavage Fluids of Horses With Severe Asthma and Correlate With Asthma Severity
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.921077
Abstract: Asthma encompasses a spectrum of heterogenous immune-mediated respiratory disorders sharing a similar clinical pattern characterized by cough, wheeze and exercise intolerance. In horses, equine asthma can be subdivided into severe or moderate asthma according to… read more here.
Keywords: asthma; neutrophil extracellular; equine asthma; severity ... See more keywords
Quantitative Transcriptome Analysis of Purified Equine Mast Cells Identifies a Dominant Mucosal Mast Cell Population with Possible Inflammatory Functions in Airways of Asthmatic Horses
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232213976
Abstract: Asthma is a chronic inflammatory airway disease and a serious health problem in horses as well as in humans. In humans and mice, mast cells (MCs) are known to be directly involved in asthma pathology… read more here.
Keywords: airways asthmatic; balf; mast; quantitative transcriptome ... See more keywords