Comparative pharmacokinetics of eleven components from active part of Gerberae Piloselloidis Herba after oral administration in control and asthmatic mice.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of separation science"
DOI: 10.1002/jssc.202101010
Abstract: Gerberae Piloselloidis Herba, a traditional Chinese medicine, is often employed to treat such lung-related diseases as coughs, asthma and pulmonary carbuncles in southwest China. Our previous study demonstrated that its active fraction, prepared from Gerberae… read more here.
Keywords: gerberae piloselloidis; asthmatic mice; piloselloidis herba; components active ... See more keywords
Long non-coding RNA NKILA alleviates airway inflammation in asthmatic mice by promoting M2 macrophage polarization and inhibiting the NF-κB pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.07.023
Abstract: Asthma remains a severe public health problem. Long non-coding RNAs (lncRNAs) are potent regulators in various diseases including asthma. This study investigated the mechanism of lncRNA NF-κB interacting lncRNA (NKILA) in asthma. The model of… read more here.
Keywords: asthmatic mice; macrophage polarization; airway inflammation; mice ... See more keywords
Genipin inhibits allergic responses in ovalbumin‐induced asthmatic mice
Sign Up to like & getrecommendations! Published in 2017 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2017.10.010
Abstract: Abstract Genipin is a natural compound isolated from the fruit of Gardenia jasminoides with various pharmacological effects. In this study, we investigated whether genipin effectively alleviates allergic responses in a murine model of ovalbumin (OVA)‐induced… read more here.
Keywords: genipin; asthmatic mice; induced asthmatic; ova ... See more keywords
Alleviating airway inflammation by inhibiting ERK‐NF‐&kgr;B signaling pathway by blocking Kv1.3 channels
Sign Up to like & getrecommendations! Published in 2018 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2018.07.009
Abstract: &NA; Allergic asthma is a chronic inflammatory disease of the airways. T lymphocytes play an important role in the pathogenesis of asthma. The voltage‐gated Kv1.3 potassium channel is a target for the preferential inhibition of… read more here.
Keywords: asthmatic mice; kgr; airway inflammation; pap ... See more keywords
PM2.5 inhibits SOD1 expression by up-regulating microRNA-206 and promotes ROS accumulation and disease progression in asthmatic mice.
Sign Up to like & getrecommendations! Published in 2019 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2019.105871
Abstract: Bronchial asthma is the most common chronic respiratory disease. Chronic airway inflammation, airflow restriction and airway hyper-responsiveness are its main manifestations. In recent decades, the prevalence and mortality of asthma have been increasing all over… read more here.
Keywords: pm2; asthmatic mice; expression; mice ... See more keywords
The neuro-immune interaction in airway inflammation through TRPA1 expression in CD4+ T cells of asthmatic mice.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.106696
Abstract: Asthma is an inflammatory disorder of the airways dominated by a Th2-type pattern. Recently, an emerging interest arises whether transient receptor potential ankyrin 1 (TRPA1) plays a potential role in the adaptive immune response. In… read more here.
Keywords: cd4 cells; trpa1; asthmatic mice; expression ... See more keywords
Immunomodulatory and anti-inflammatory effects of Aerva lanata in ovalbumin induced allergic asthmatic mice.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2022.115087
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Aerva lanata Linn. (A. lanata) is traditionally used for cough, sore throat and asthma. AIM OF STUDY The aim of the present study was to investigate the immunomodulatory and anti-inflammatory potentials of A.… read more here.
Keywords: asthmatic mice; mice; allergic asthmatic; immunomodulatory anti ... See more keywords
An exopolysaccharide from Bacillus subtilis alleviates airway inflammatory responses via the NF-κB and STAT6 pathways in asthmatic mice
Sign Up to like & getrecommendations! Published in 2022 at "Bioscience Reports"
DOI: 10.1042/bsr20212461
Abstract: Abstract Bacillus subtilis is an intestinal probiotic for immune homeostasis and its exopolysaccharide (EPS) is known to possess anti-inflammatory and antioxidant properties. The underlying mechanisms are not yet fully understood. In the present study, we… read more here.
Keywords: stat6; bacillus subtilis; eps treatment; asthmatic mice ... See more keywords
PM2.5 aggravates airway inflammation in asthmatic mice: activating NF-κB via MyD88 signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Environmental Health Research"
DOI: 10.1080/09603123.2022.2041561
Abstract: ABSTRACT The role of PM2.5 in the bronchial asthma remains unclear. In this study, the deficient mice of TLR4-/-, TLR2-/- and MyD88 -/- were used to establish asthma model. The effects of PM2.5 on the… read more here.
Keywords: signaling pathway; myd88; myd88 signaling; pm2 ... See more keywords
Histone deacetylase 8 regulates NF-κB-related inflammation in asthmatic mice through H3K9 acetylation
Sign Up to like & getrecommendations! Published in 2022 at "Chinese Medical Journal"
DOI: 10.1097/cm9.0000000000001963
Abstract: To the Editor: Bronchial asthma is a respiratory disease with pathological features that mainly comprise changes in airway inflammation, airway remodeling, and airway hyperresponsiveness. During an asthma attack, a large number of inflammatory genes are… read more here.
Keywords: inflammation asthmatic; related inflammation; regulates related; asthmatic mice ... See more keywords
Oral administration of Lactobacillus plantarum CQPC11 attenuated the airway inflammation in an ovalbumin (OVA)-induced Balb/c mouse model of asthma.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of food biochemistry"
DOI: 10.1111/jfbc.14036
Abstract: This study investigated the antiasthmatic and anti-inflammatory effects of Lactobacillus plantarum-CQPC11 (LP-CQPC11) on ovalbumin (OVA)-induced asthmatic Balb/c mice. Administration of different doses of LP-CQPC11 (105 , 107 , and 109 colony-forming unit [CFU]/mouse) effectively reduced… read more here.
Keywords: administration; asthmatic mice; cqpc11; ova induced ... See more keywords