Inhibitors of BRD4 protein from the roots of Astilbe grandis stapf ex E.H. Wilson
Sign Up to like & getrecommendations! Published in 2019 at "Natural Product Research"
DOI: 10.1080/14786419.2019.1655414
Abstract: Abstract A new monoterpene (1) along with eight known compounds were isolated from the roots of Astilbe grandis Stapf ex E.H. Wilson. Their structures were determined by extensive spectroscopic analysis and ECD experiments as (S)-3-(2-hydroxyethyl)-5-(2-methylprop-1-en-1-yl)furan-2(5H)-one… read more here.
Keywords: astilbe grandis; stapf wilson; brd4 protein; grandis stapf ... See more keywords
Triterpenoid acids characterized by the oxidation of the C-27-methy from the roots of Astilbe grandis Stapf ex Wils.
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DOI: 10.2139/ssrn.4374426
Abstract: Two unprecedented oleane-type triterpenes (5-6) were isolated from the roots of Astilbe grandis Stapf ex Wils, along with four known triterpenes (1-4), all of which were separated from this plant for the first time. The… read more here.
Keywords: roots astilbe; stapf wils; triterpenoid acids; grandis stapf ... See more keywords
Oleanane triterpenoids with C-14 carboxyl group from Astilbe grandis inhibited LPS-induced macrophages activation by suppressing the NF-κB signaling pathway
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DOI: 10.3389/fphar.2024.1413876
Abstract: Background Excessive inflammation poses significant risks to human physical and mental health. Astilbe grandis, a traditional Miao medicine, is renowned for its anti-inflammatory properties. However, the specific anti-inflammatory effects and mechanisms of many compounds within… read more here.
Keywords: astilbe grandis; oleanane triterpenoids; lps induced; anti inflammatory ... See more keywords