AQP4 Aggravates Cognitive Impairment in Sepsis‐Associated Encephalopathy through Inhibiting Nav1.6‐Mediated Astrocyte Autophagy
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DOI: 10.1002/advs.202205862
Abstract: The pathology of sepsis‐associated encephalopathy (SAE) is related to astrocyte‐inflammation associated with aquaporin‐4 (AQP4). The aim here is to investigate the effects of AQP4 associated with SAE and reveal its underlying mechanism causing cognitive impairment.… read more here.
Keywords: associated encephalopathy; cognitive impairment; sepsis associated; astrocyte ... See more keywords
Sulfatase‐mediated manipulation of the astrocyte‐Schwann cell interface
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DOI: 10.1002/glia.23047
Abstract: Schwann cell (SC) transplantation following spinal cord injury (SCI) may have therapeutic potential. Functional recovery is limited however, due to poor SC interactions with host astrocytes and the induction of astrogliosis. Olfactory ensheathing cells (OECs)… read more here.
Keywords: sulfatase mediated; sulfatase; astrocyte; schwann cell ... See more keywords
Melanopsin for precise optogenetic activation of astrocyte‐neuron networks
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DOI: 10.1002/glia.23580
Abstract: Optogenetics has been widely expanded to enhance or suppress neuronal activity and it has been recently applied to glial cells. Here, we have used a new approach based on selective expression of melanopsin, a G‐protein‐coupled… read more here.
Keywords: optogenetic activation; melanopsin precise; astrocyte; neuron ... See more keywords
Microglia maintain the normal structure and function of the hippocampal astrocyte network
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DOI: 10.1002/glia.24179
Abstract: Microglial control of activity‐dependent plasticity and synaptic remodeling in neuronal networks has been the subject of intense research in the past several years. Although microglia–neuron interactions have been extensively studied, less is known about how… read more here.
Keywords: structure function; astrocyte; function; synaptic transmission ... See more keywords
Ezrin deficiency triggers glial fibrillary acidic protein upregulation and a distinct reactive astrocyte phenotype
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DOI: 10.1002/glia.24253
Abstract: Astrocytes are increasingly being recognized as contributors to physiological brain function and behavior. Astrocytes engage in glia‐synaptic interactions through peripheral astrocyte processes, thus modulating synaptic signaling, for example, by handling glutamate removal from the synaptic… read more here.
Keywords: fibrillary acidic; ezrin; protein upregulation; acidic protein ... See more keywords
Reactive microglia are the major source of tumor necrosis factor alpha and contribute to astrocyte dysfunction and acute seizures in experimental temporal lobe epilepsy
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DOI: 10.1002/glia.24265
Abstract: Extensive microglia reactivity has been well described in human and experimental temporal lobe epilepsy (TLE). To date, however, it is not clear whether and based on which molecular mechanisms microglia contribute to the development and… read more here.
Keywords: reactive microglia; factor; epilepsy; astrocyte dysfunction ... See more keywords
Transcription factor combinations that define human astrocyte identity encode significant variation of maturity and function.
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DOI: 10.1002/glia.24372
Abstract: Increasing evidence indicates that cellular identity can be reduced to the distinct gene regulatory networks controlled by transcription factors (TFs). However, redundancy exists in these states as different combinations of TFs can induce broadly similar… read more here.
Keywords: function; transcription; identity; maturity ... See more keywords
IL‐10 and Cdc42 modulate astrocyte‐mediated microglia activation in methamphetamine‐induced neuroinflammation
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DOI: 10.1002/glia.24542
Abstract: Methamphetamine (Meth) use is known to induce complex neuroinflammatory responses, particularly involving astrocytes and microglia. Building upon our previous research, which demonstrated that Meth stimulates astrocytes to release tumor necrosis factor (TNF) and glutamate, leading… read more here.
Keywords: astrocyte; activation; methamphetamine; cdc42 ... See more keywords
Astrocyte‐Specific Phenotyping of FAD4T as an Alzheimer's Disease Mouse Model
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DOI: 10.1002/glia.70002
Abstract: Alzheimer's disease (AD) is the most prevalent neurodegenerative disease, characterized by memory decline and behavioral changes. Its pathological features include senile plaques, neurofibrillary tangles, and reactive gliosis, comprising abnormal accumulations of β‐amyloid peptide (Aβ) and… read more here.
Keywords: alzheimer disease; disease; astrocyte; mouse model ... See more keywords
Specificity of exogenous acetate and glutamate as astrocyte substrates examined in acute brain slices from female mice using methionine sulfoximine (MSO) to inhibit glutamine synthesis
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24038
Abstract: Removal of endogenously released glutamate is mediated primarily by astrocytes and exogenous 13C‐labeled glutamate has been applied to study glutamate metabolism in astrocytes. Likewise, studies have clearly established the relevance of 13C‐labeled acetate as an… read more here.
Keywords: mso; astrocyte; acetate; acetate glutamate ... See more keywords
Physiology of Astroglia.
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DOI: 10.1007/978-981-13-9913-8_3
Abstract: Astrocytes are principal cells responsible for maintaining the brain homeostasis. Additionally, these glial cells are also involved in homocellular (astrocyte-astrocyte) and heterocellular (astrocyte-other cell types) signalling and metabolism. These astroglial functions require an expression of… read more here.
Keywords: physiology; physiology astroglia; biology; astrocyte ... See more keywords