Quercetin reduces neural tissue damage and promotes astrocyte activation after spinal cord injury in rats
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26392
Abstract: Spinal cord injury (SCI) is lead to locomotor impairment because of neurological damage after following trauma. Quercetin (Que) has been confirmed to have a neuro‐protective effect during nerve damage processes. The purpose of this study… read more here.
Keywords: sci; astrocyte activation; activation; damage ... See more keywords
The Long Non-coding RNA NEAT1/miR-224-5p/IL-33 Axis Modulates Macrophage M2a Polarization and A1 Astrocyte Activation.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular neurobiology"
DOI: 10.1007/s12035-021-02405-x
Abstract: To identify potential regulators and investigate the molecular mechanism of macrophage polarization affecting astrocyte activation from the perspective of non-coding RNA regulation, we isolated mouse bone marrow mononuclear cells (BMMNCs)-induced macrophages toward M1 or M2a… read more here.
Keywords: astrocyte activation; mir 224; activation; neat1 knockdown ... See more keywords
Alpha-pinene and dizocilpine (MK-801) attenuate kindling development and astrocytosis in an experimental mouse model of epilepsy
Sign Up to like & getrecommendations! Published in 2020 at "IBRO Reports"
DOI: 10.1016/j.ibror.2020.07.007
Abstract: Understanding the molecular and cellular mechanisms involved during the onset of epilepsy is crucial for elucidating the overall mechanism of epileptogenesis and therapeutic strategies. Previous studies, using a pentylenetetrazole (PTZ)-induced kindling mouse model, showed that… read more here.
Keywords: astrocyte activation; pinene; ecm; mouse model ... See more keywords
Gut Microbiota from Short-Chain Chlorinated Paraffin-Exposed Mice Promotes Astrocyte Activation by Disrupting the Intestinal Tight Junction via Zonulin Upregulation.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.3c01058
Abstract: Short-chain chlorinated paraffins (SCCPs) are novel toxicants in food and are reported to possess neurotoxicity. Here, we investigated the mechanism of SCCP-induced astrocyte activation and neuroinflammation. SCCP gavage induced astrocyte activation and neuronal cell death… read more here.
Keywords: tight junction; sccp; astrocyte activation; mice ... See more keywords
Aspirin suppresses neuronal apoptosis, reduces tissue inflammation, and restrains astrocyte activation by activating the Nrf2/HO-1 signaling pathway
Sign Up to like & getrecommendations! Published in 2018 at "NeuroReport"
DOI: 10.1097/wnr.0000000000000969
Abstract: The nuclear factor E2-related factor 2 (Nrf2)/antioxidant response element signaling pathway plays a substantial role in preventing oxidative stress-related diseases. Aspirin has been shown to exert several pharmacological effects by inducing the expression of the… read more here.
Keywords: astrocyte activation; inflammation; nrf2 signaling; signaling pathway ... See more keywords
Wnt10a/β‐catenin signalling is involved in kindlin‐1‐mediated astrocyte activation in a chronic construction injury rat model
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Neuroscience"
DOI: 10.1111/ejn.15488
Abstract: The activation of spinal astrocytes and release of neuroinflammatory mediators are important events in neuropathic pain (NP) pathogenesis. In this study, we investigated the role of Wnt10a/β‐catenin signalling in kindlin‐1‐mediated astrocyte activation using a chronic… read more here.
Keywords: astrocyte activation; mediated astrocyte; activation; kindlin mediated ... See more keywords
Mapping microglia and astrocyte activation in vivo using diffusion MRI
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abq2923
Abstract: While glia are increasingly implicated in the pathophysiology of psychiatric and neurodegenerative disorders, available methods for imaging these cells in vivo involve either invasive procedures or positron emission tomography radiotracers, which afford low resolution and… read more here.
Keywords: diffusion; astrocyte activation; mri; microglia astrocyte ... See more keywords
Role of bone morphogenetic protein-2/4 in astrocyte activation in neuropathic pain
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Pain"
DOI: 10.1177/1744806919892100
Abstract: Background Bone morphogenetic protein-2/4 (BMP2/4) has been recognized as promoters of astrocyte activity. Substantial evidence suggests that BMP2/4 may be elevated and plays a critical role in astrocyte activation upon spinal cord injury. Although neuropathic… read more here.
Keywords: protein; astrocyte activation; bmp2; neuropathic pain ... See more keywords
Netrin-1 attenuates brain injury after middle cerebral artery occlusion via downregulation of astrocyte activation in mice
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-018-1291-5
Abstract: BackgroundNetrin-1 functions largely via combined receptors and downstream effectors. Evidence has shown that astrocytes express netrin-1 receptors, including DCC and UNC5H2. However, whether netrin-1 influences the function of astrocytes was previously unknown.MethodsLipopolysaccharide was used to… read more here.
Keywords: cerebral artery; astrocyte activation; middle cerebral; activation ... See more keywords
TRPV1 mediates astrocyte activation and interleukin-1β release induced by hypoxic ischemia (HI)
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-019-1487-3
Abstract: BackgroundHypoxic-ischemic encephalopathy (HIE) is a serious birth complication with high incidence in both advanced and developing countries. Children surviving from HIE often have severe long-term sequela including cerebral palsy, epilepsy, and cognitive disabilities. The severity… read more here.
Keywords: trpv1; hypoxic ischemia; astrocyte activation; activation ... See more keywords
Upregulated miR-125b mitigates inflammation, astrocyte activation, and dysfunction of spinal cord injury by inactivating the MAPK pathway.
Sign Up to like & getrecommendations! Published in 2023 at "Histology and histopathology"
DOI: 10.14670/hh-18-624
Abstract: BACKGROUND Since the abnormal expression of miR-125b in spinal cord injury (SCI) and the regulatory effect of miR-125b on the MAPK pathway have been expounded, we attempt to investigate whether miR-125b exerts a regulatory effect… read more here.
Keywords: inflammation; mir 125b; astrocyte activation; mapk pathway ... See more keywords