Sirtuin 3 regulates astrocyte activation by reducing Notch1 signaling after status epilepticus
Sign Up to like & getrecommendations! Published in 2024 at "Glia"
DOI: 10.1002/glia.24520
Abstract: Sirtuin3 (Sirt3) is a nicotinamide adenine dinucleotide enzyme that contributes to aging, cancer, and neurodegenerative diseases. Recent studies have reported that Sirt3 exerts anti‐inflammatory effects in several neuropathophysiological disorders. As epilepsy is a common neurological… read more here.
Keywords: regulates astrocyte; notch1 signaling; sirt3; activation ... See more keywords
Quercetin reduces neural tissue damage and promotes astrocyte activation after spinal cord injury in rats
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26392
Abstract: Spinal cord injury (SCI) is lead to locomotor impairment because of neurological damage after following trauma. Quercetin (Que) has been confirmed to have a neuro‐protective effect during nerve damage processes. The purpose of this study… read more here.
Keywords: sci; astrocyte activation; activation; damage ... See more keywords
Heterogeneity of brain extracellular matrix and astrocyte activation
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.25356
Abstract: From the blood brain barrier to the synaptic space, astrocytes provide structural, metabolic, ionic, and extracellular matrix (ECM) support across the brain. Astrocytes include a vast array of subtypes, their phenotypes and functions varying both… read more here.
Keywords: extracellular matrix; astrocyte activation; brain; activation ... See more keywords
MTOR Promotes Astrocyte Activation and Participates in Neuropathic Pain through an Upregulation of RIP3
Sign Up to like & getrecommendations! Published in 2025 at "Neurochemical Research"
DOI: 10.1007/s11064-025-04341-x
Abstract: Neuropathic pain (NP), a chronic pain condition, is the result of abnormalities in both central and peripheral pain conduction pathways. Here, we investigated the underlying mechanisms associated with this effect. We found that following chronic… read more here.
Keywords: rip3; activation; astrocyte activation; neuropathic pain ... See more keywords
The Long Non-coding RNA NEAT1/miR-224-5p/IL-33 Axis Modulates Macrophage M2a Polarization and A1 Astrocyte Activation.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular neurobiology"
DOI: 10.1007/s12035-021-02405-x
Abstract: To identify potential regulators and investigate the molecular mechanism of macrophage polarization affecting astrocyte activation from the perspective of non-coding RNA regulation, we isolated mouse bone marrow mononuclear cells (BMMNCs)-induced macrophages toward M1 or M2a… read more here.
Keywords: astrocyte activation; mir 224; activation; neat1 knockdown ... See more keywords
Alpha-pinene and dizocilpine (MK-801) attenuate kindling development and astrocytosis in an experimental mouse model of epilepsy
Sign Up to like & getrecommendations! Published in 2020 at "IBRO Reports"
DOI: 10.1016/j.ibror.2020.07.007
Abstract: Understanding the molecular and cellular mechanisms involved during the onset of epilepsy is crucial for elucidating the overall mechanism of epileptogenesis and therapeutic strategies. Previous studies, using a pentylenetetrazole (PTZ)-induced kindling mouse model, showed that… read more here.
Keywords: astrocyte activation; pinene; ecm; mouse model ... See more keywords
Gut Microbiota from Short-Chain Chlorinated Paraffin-Exposed Mice Promotes Astrocyte Activation by Disrupting the Intestinal Tight Junction via Zonulin Upregulation.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.3c01058
Abstract: Short-chain chlorinated paraffins (SCCPs) are novel toxicants in food and are reported to possess neurotoxicity. Here, we investigated the mechanism of SCCP-induced astrocyte activation and neuroinflammation. SCCP gavage induced astrocyte activation and neuronal cell death… read more here.
Keywords: tight junction; sccp; astrocyte activation; mice ... See more keywords
Aspirin suppresses neuronal apoptosis, reduces tissue inflammation, and restrains astrocyte activation by activating the Nrf2/HO-1 signaling pathway
Sign Up to like & getrecommendations! Published in 2018 at "NeuroReport"
DOI: 10.1097/wnr.0000000000000969
Abstract: The nuclear factor E2-related factor 2 (Nrf2)/antioxidant response element signaling pathway plays a substantial role in preventing oxidative stress-related diseases. Aspirin has been shown to exert several pharmacological effects by inducing the expression of the… read more here.
Keywords: astrocyte activation; inflammation; nrf2 signaling; signaling pathway ... See more keywords
Wnt10a/β‐catenin signalling is involved in kindlin‐1‐mediated astrocyte activation in a chronic construction injury rat model
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Neuroscience"
DOI: 10.1111/ejn.15488
Abstract: The activation of spinal astrocytes and release of neuroinflammatory mediators are important events in neuropathic pain (NP) pathogenesis. In this study, we investigated the role of Wnt10a/β‐catenin signalling in kindlin‐1‐mediated astrocyte activation using a chronic… read more here.
Keywords: astrocyte activation; mediated astrocyte; activation; kindlin mediated ... See more keywords
DJ‐1 regulates astrocyte activation through miR‐155/SHP‐1 signaling in cerebral ischemia/reperfusion injury
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.16230
Abstract: Reactive astrocyte activation in the context of cerebral ischemia/reperfusion (I/R) injury gives rise to two distinct subtypes: the neurotoxic A1 type and the neuroprotective A2 type. DJ‐1 (Parkinson disease protein 7, PARK7), originally identified as… read more here.
Keywords: reperfusion; cerebral ischemia; mir 155; injury ... See more keywords
Mapping microglia and astrocyte activation in vivo using diffusion MRI
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abq2923
Abstract: While glia are increasingly implicated in the pathophysiology of psychiatric and neurodegenerative disorders, available methods for imaging these cells in vivo involve either invasive procedures or positron emission tomography radiotracers, which afford low resolution and… read more here.
Keywords: diffusion; astrocyte activation; mri; microglia astrocyte ... See more keywords