Reactive microglia are the major source of tumor necrosis factor alpha and contribute to astrocyte dysfunction and acute seizures in experimental temporal lobe epilepsy
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24265
Abstract: Extensive microglia reactivity has been well described in human and experimental temporal lobe epilepsy (TLE). To date, however, it is not clear whether and based on which molecular mechanisms microglia contribute to the development and… read more here.
Keywords: reactive microglia; factor; epilepsy; astrocyte dysfunction ... See more keywords
Examining the relationship between astrocyte dysfunction and neurodegeneration in ALS using hiPSCs
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DOI: 10.1016/j.nbd.2019.104562
Abstract: Amyotrophic lateral sclerosis (ALS) is a complex and fatal neurodegenerative disease for which the causes of disease onset and progression remain unclear. Recent advances in human induced pluripotent stem cell (hiPSC)-based models permit the study… read more here.
Keywords: dysfunction neurodegeneration; examining relationship; dysfunction; disease ... See more keywords
Potential of Multiscale Astrocyte Imaging for Revealing Mechanisms Underlying Neurodevelopmental Disorders
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms221910312
Abstract: Astrocytes provide trophic and metabolic support to neurons and modulate circuit formation during development. In addition, astrocytes help maintain neuronal homeostasis through neurovascular coupling, blood–brain barrier maintenance, clearance of metabolites and nonfunctional proteins via the… read more here.
Keywords: potential multiscale; astrocyte; multiscale astrocyte; astrocyte dysfunction ... See more keywords