Astrocyte‐mediated synapse remodeling in the pathological brain
Sign Up to like & getrecommendations! Published in 2017 at "Glia"
DOI: 10.1002/glia.23169
Abstract: Astrocytes, a major type of glia, reciprocally influence synaptic transmission and connectivity, forming the “tripartite synapses”. Astrocytic metabotropic glutamate receptor (mGluR)‐mediated Ca2+ waves and release of gliotransmitters or synaptogenic molecules mediate this neuron‐glia interaction in… read more here.
Keywords: synapse; pathological brain; mediated synapse; astrocyte mediated ... See more keywords
Cx43 hemichannels contribute to astrocyte-mediated toxicity in sporadic and familial ALS
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2107391119
Abstract: Significance Our results demonstrate that connexin 43 hemichannels are the conduits for amyotrophic lateral sclerosis (ALS) astrocyte-mediated motor neuron toxicity and disease spread, acting as a common mechanism that can target both familial ALS and… read more here.
Keywords: familial als; contribute astrocyte; astrocyte mediated; cx43 hemichannels ... See more keywords
Astrocyte-mediated spike-timing-dependent long-term depression modulates synaptic properties in the developing cortex
Sign Up to like & getrecommendations! Published in 2020 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1008360
Abstract: Astrocytes have been shown to modulate synaptic transmission and plasticity in specific cortical synapses, but our understanding of the underlying molecular and cellular mechanisms remains limited. Here we present a new biophysicochemical model of a… read more here.
Keywords: spike timing; long term; dependent long; astrocyte mediated ... See more keywords
The Function of Astrocyte Mediated Extracellular Vesicles in Central Nervous System Diseases
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2020.568889
Abstract: Astrocyte activation plays an important role during disease-induced inflammatory response in the brain. Exosomes in the brain could be released from bone marrow (BM)-derived stem cells, neuro stem cells (NSC), mesenchymal stem cells (MSC), etc.… read more here.
Keywords: mediated extracellular; astrocyte mediated; function astrocyte; brain ... See more keywords
Long Non-coding RNAs and Circular RNAs: Insights Into Microglia and Astrocyte Mediated Neurological Diseases
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2021.745066
Abstract: Microglia and astrocytes maintain tissue homeostasis in the nervous system. Both microglia and astrocytes have pro-inflammatory phenotype and anti-inflammatory phenotype. Activated microglia and activated astrocytes can contribute to several neurological diseases. Long non-coding RNAs (lncRNAs)… read more here.
Keywords: microglia astrocyte; coding rnas; astrocyte mediated; non coding ... See more keywords