Transcriptomic analyses of NeuroD1‐mediated astrocyte‐to‐neuron conversion
Sign Up to like & getrecommendations! Published in 2022 at "Developmental Neurobiology"
DOI: 10.1002/dneu.22882
Abstract: Ectopic expression of a single neural transcription factor NeuroD1 can reprogram reactive glial cells into functional neurons both in vitro and in vivo, but the underlying mechanisms are not well understood yet. Here, we used… read more here.
Keywords: neurod1 mediated; neuron conversion; conversion; astrocyte neuron ... See more keywords
Neuron–astrocyte signaling is preserved in the aging brain
Sign Up to like & getrecommendations! Published in 2017 at "Glia"
DOI: 10.1002/glia.23112
Abstract: Astrocytes play crucial roles in brain homeostasis and are emerging as regulatory elements of neuronal and synaptic physiology by responding to neurotransmitters with Ca2+ elevations and releasing gliotransmitters that activate neuronal receptors. Aging involves neuronal… read more here.
Keywords: astrocyte neuron; physiology; brain; aging brain ... See more keywords
Ethanol induces interferon expression in neurons via TRAIL: role of astrocyte-to-neuron signaling
Sign Up to like & getrecommendations! Published in 2019 at "Psychopharmacology"
DOI: 10.1007/s00213-018-5153-8
Abstract: RationaleAlcohol use disorder (AUD) involves dysregulation of innate immune signaling in brain. Toll-like receptor 3 (TLR3), an innate immune receptor that is upregulated in post-mortem human alcoholics, leads to induction of interferon (IFN) signaling. IFNs… read more here.
Keywords: role astrocyte; trail; astrocyte neuron; ifn ... See more keywords
Disruption of the astrocyte–neuron interaction is responsible for the impairments in learning and memory in 5XFAD mice: an Alzheimer’s disease animal model
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Brain"
DOI: 10.1186/s13041-021-00823-5
Abstract: The morphological dynamics of astrocytes are altered in the hippocampus during memory induction. Astrocyte–neuron interactions on synapses are called tripartite synapses. These control the synaptic function in the central nervous system. Astrocytes are activated in… read more here.
Keywords: astrocyte neuron; 5xfad mice; memory; neuron interactions ... See more keywords
Regeneration of Functional Neurons After Spinal Cord Injury via in situ NeuroD1-Mediated Astrocyte-to-Neuron Conversion
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2020.591883
Abstract: Spinal cord injury (SCI) often leads to impaired motor and sensory functions, partially because the injury-induced neuronal loss cannot be easily replenished through endogenous mechanisms. In vivo neuronal reprogramming has emerged as a novel technology… read more here.
Keywords: neuron conversion; astrocyte neuron; regeneration; conversion ... See more keywords
Astrocyte-Neuron Signaling in Synaptogenesis
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.680301
Abstract: Astrocytes are the key component of the central nervous system (CNS), serving as pivotal regulators of neuronal synapse formation and maturation through their ability to dynamically and bidirectionally communicate with synapses throughout life. In the… read more here.
Keywords: synaptogenesis; signaling synaptogenesis; astrocyte neuron; neuron ... See more keywords
Astrocyte–Neuron Networks: A Multilane Highway of Signaling for Homeostatic Brain Function
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Synaptic Neuroscience"
DOI: 10.3389/fnsyn.2018.00045
Abstract: Research on glial cells over the past 30 years has confirmed the critical role of astrocytes in pathophysiological brain states. However, most of our knowledge about astrocyte physiology and of the interactions between astrocytes and… read more here.
Keywords: highway signaling; astrocyte neuron; neuron networks; multilane highway ... See more keywords
Modulation of the Astrocyte-Neuron Lactate Shuttle System contributes to Neuroprotective action of Fibroblast Growth Factor 21
Sign Up to like & getrecommendations! Published in 2020 at "Theranostics"
DOI: 10.7150/thno.44370
Abstract: A viewpoint considering Alzheimer's disease (AD) as “type 3 diabetes” emphasizes the pivotal role of dysfunctional brain energy metabolism in AD. The hormone fibroblast growth factor 21 (FGF21) is a crucial regulator in energy metabolism;… read more here.
Keywords: system; astrocyte neuron; neuron lactate; lactate shuttle ... See more keywords