Human iPSC-derived astrocytes from ALS patients with mutated C9ORF72 show increased oxidative stress and neurotoxicity
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DOI: 10.1016/j.ebiom.2019.11.026
Abstract: Background Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects motor neurons (MNs). It was shown that human astrocytes with mutations in genes associated with ALS, like C9orf72 (C9) or SOD1, reduce survival… read more here.
Keywords: oxidative stress; stress; show increased; astrocytes als ... See more keywords