Microtubule organization and dynamics in oligodendrocytes, astrocytes, and microglia
Sign Up to like & getrecommendations! Published in 2020 at "Developmental Neurobiology"
DOI: 10.1002/dneu.22753
Abstract: Though much is known about microtubule organization and microtubule‐based transport in neurons, the development and function of microtubules in glia are more enigmatic. In this review, we provide an overview of the literature on microtubules… read more here.
Keywords: organization dynamics; microtubule organization; oligodendrocytes astrocytes; astrocytes microglia ... See more keywords
Imaging of translocator protein upregulation is selective for pro‐inflammatory polarized astrocytes and microglia
Sign Up to like & getrecommendations! Published in 2019 at "Glia"
DOI: 10.1002/glia.23716
Abstract: Translocator protein (TSPO) expression is increased in activated glia, and has been used as a marker of neuroinflammation in PET imaging. However, the extent to which TSPO upregulation reflects a pro‐ or anti‐inflammatory phenotype remains… read more here.
Keywords: astrocytes microglia; translocator protein; inflammatory; upregulation ... See more keywords
Diverse human astrocyte and microglial transcriptional responses to Alzheimer’s pathology
Sign Up to like & getrecommendations! Published in 2021 at "Acta Neuropathologica"
DOI: 10.1007/s00401-021-02372-6
Abstract: To better define roles that astrocytes and microglia play in Alzheimer’s disease (AD), we used single-nuclei RNA-sequencing to comprehensively characterise transcriptomes in astrocyte and microglia nuclei selectively enriched during isolation post-mortem from neuropathologically defined AD… read more here.
Keywords: microglial transcriptional; diverse human; astrocytes microglia; pathology ... See more keywords
Platelet CD40L induces activation of astrocytes and microglia in hypertension
Sign Up to like & getrecommendations! Published in 2017 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2016.09.021
Abstract: Studies have demonstrated separately that hypertension is associated with platelet activation in the periphery (resulting in accumulation and localized inflammatory response) and glial activation in the brain. We investigated the contribution of platelets in brain… read more here.
Keywords: activation astrocytes; astrocytes microglia; cd40l; activation ... See more keywords
Type I astrocytes and microglia induce a cytokine response in an encephalitic murine coronavirus infection
Sign Up to like & getrecommendations! Published in 2020 at "Experimental and Molecular Pathology"
DOI: 10.1016/j.yexmp.2020.104474
Abstract: Abstract The pathogenesis of viral infections involves an immune response by cytokines, causing a deleterious effect on organ function, in addition to tissue destruction due to viral replication. Clinical symptoms and laboratory findings of the… read more here.
Keywords: astrocytes microglia; response; infection; coronavirus ... See more keywords
Pathological tau signatures and nuclear alterations in neurons, astrocytes and microglia in Alzheimer's disease, progressive supranuclear palsy, and dementia with Lewy bodies
Sign Up to like & getrecommendations! Published in 2022 at "Brain Pathology"
DOI: 10.1111/bpa.13112
Abstract: Accumulation of pathological tau aggregates is a prominent feature in tauopathies that leads during the course of the diseases to neuronal dysfunction before and cell death after. Microglia and astrocytes have been described as playing… read more here.
Keywords: cell; tau; disease; pathology ... See more keywords
Hepcidin attenuates amyloid beta‐induced inflammatory and pro‐oxidant responses in astrocytes and microglia
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.14005
Abstract: Alzheimer's disease (AD) is characterized by extracellular senile plaques, intracellular neurofibrillary tangles, and neuronal death. Aggregated amyloid‐β (Aβ) induces inflammation and oxidative stress, which have pivotal roles in the pathogenesis of AD. Hepcidin is a… read more here.
Keywords: anti inflammatory; pro oxidant; astrocytes microglia; inflammatory pro ... See more keywords
Sphingosine 1‐phosphate receptors regulate TLR4‐induced CXCL5 release from astrocytes and microglia
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.14313
Abstract: Sphingosine 1‐phosphate receptors (S1PR) are G protein‐coupled and compose a family with five subtypes, S1P1R–S1P5R. The drug Gilenya® (Novartis, Basel, Switzerland) (Fingolimod; FTY720) targets S1PRs and was the first oral therapy for patients with relapsing‐remitting… read more here.
Keywords: sphingosine phosphate; astrocytes microglia; chemokine; release ... See more keywords
Astrocytes and microglia play orchestrated roles and respect phagocytic territories during neuronal corpse removal in vivo
Sign Up to like & getrecommendations! Published in 2020 at "Science Advances"
DOI: 10.1126/sciadv.aba3239
Abstract: Astrocytes and microglia have specialized roles and display a coordinated response during corpse removal in the live brain. Cell death is prevalent throughout life; however, the coordinated interactions and roles of phagocytes during corpse removal… read more here.
Keywords: corpse removal; astrocytes microglia; removal; microglia play ... See more keywords
Crosstalk between astrocytes and microglia results in increased degradation of α-synuclein and amyloid-β aggregates
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-021-02158-3
Abstract: Background Alzheimer’s disease (AD) and Parkinson’s disease (PD) are characterized by brain accumulation of aggregated amyloid-beta (Aβ) and alpha-synuclein (αSYN), respectively. In order to develop effective therapies, it is crucial to understand how the Aβ/αSYN… read more here.
Keywords: protein; degradation; astrocytes microglia; synuclein ... See more keywords
Cyclic multiplex fluorescent immunohistochemistry and machine learning reveal distinct states of astrocytes and microglia in normal aging and Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-022-02383-4
Abstract: Background Astrocytes and microglia react to Aβ plaques, neurofibrillary tangles, and neurodegeneration in the Alzheimer’s disease (AD) brain. Single-nuclei and single-cell RNA-seq have revealed multiple states or subpopulations of these glial cells but lack spatial… read more here.
Keywords: fluorescent immunohistochemistry; machine learning; multiplex fluorescent; astrocytes microglia ... See more keywords