Vascular endothelial growth factor promotes transdifferentiation of astrocytes into neurons via activation of the MAPK/Erk‐Pax6 signal pathway
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DOI: 10.1002/glia.24361
Abstract: Reactive astrocytes can be transformed into new neurons. Vascular endothelial growth factor (VEGF) promotes the transformation of reactive astrocytes into neurons in ischemic brain. Therefore, in this study, the molecular mechanism of VEGF's effect on… read more here.
Keywords: vegf enhanced; vegf; mapk erk; astrocytes neurons ... See more keywords
Oxidative stress induces release of 2’-AMP from microglia
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DOI: 10.1016/j.brainres.2018.11.002
Abstract: BACKGROUND Microglia metabolize exogenous 2'-AMP and 3'-AMP (non-canonical nucleotides) to adenosine and exogenous 2'-AMP and 3'-AMP (via conversion to adenosine) inhibit the production of inflammatory cytokines by microglia. This suggests that if microglia release endogenous… read more here.
Keywords: amp; amp amp; release; astrocytes neurons ... See more keywords
Correlation of optical attenuation coefficient estimated using optical coherence tomography with changes in astrocytes and neurons in a chronic photothrombosis stroke model.
Sign Up to like & getrecommendations! Published in 2019 at "Biomedical optics express"
DOI: 10.1364/boe.10.006258
Abstract: The optical attenuation coefficient (OAC) estimated using optical coherence tomography (OAC-OCT) offers a label-free 3D mapping of tissue infarction, but the physiological origin of the OAC contrast remains unclear. For effectively suppressing OAC fluctuations, we… read more here.
Keywords: optical attenuation; contrast; changes astrocytes; infarction ... See more keywords
Transdifferentiating Astrocytes Into Neurons Using ASCL1 Functionalized With a Novel Intracellular Protein Delivery Technology
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2018.00173
Abstract: Cellular transdifferentiation changes mature cells from one phenotype into another by altering their gene expression patterns. Manipulating expression of transcription factors, proteins that bind to DNA promoter regions, regulates the levels of key developmental genes.… read more here.
Keywords: protein; transcription; delivery; transdifferentiating astrocytes ... See more keywords
Very Low Efficiency of Direct Reprogramming of Astrocytes Into Neurons in the Brains of Young and Aged Mice After Cerebral Ischemia
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DOI: 10.3389/fnagi.2019.00334
Abstract: After cerebral ischemia, the ratio between astroglial cells and neurons in the neurovascular unit is disrupted in the perilesional area. We hypothesized that restoring the balance within the neurovascular unit may lead to an improved… read more here.
Keywords: cerebral ischemia; young aged; aged mice; ischemia ... See more keywords