Paeonol inhibits chronic constriction injury‐induced astrocytic activation and neuroinflammation in rats via the HDAC/miR‐15a pathway
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development Research"
DOI: 10.1002/ddr.21993
Abstract: Neuropathic pain affects millions of people in the worldwide, but the major therapeutics perform limited effectiveness. Paeonol (PAE) is widely distributed in Paeonis albiflora, and has manifested anti‐inflammatory and antioxidative effects in multiple diseases. The… read more here.
Keywords: hdac mir; paeonol; astrocytic activation; constriction injury ... See more keywords
The Protective Effects of AT2R Agonist, CGP42112A, Against Angiotensin II-Induced Oxidative Stress and Inflammatory Response in Astrocytes: Role of AT2R/PP2A/NFκB/ROS Signaling.
Sign Up to like & getrecommendations! Published in 2021 at "Neurotoxicity research"
DOI: 10.1007/s12640-021-00403-4
Abstract: Angiotensin II receptor type 2 (AT2R) agonists have been known to promote neuroprotection by limiting ischemic insult, neuronal proliferation, and differentiation. Further, AT2R agonists have also been associated with the suppression of neuroinflammation and neurodegeneration.… read more here.
Keywords: role at2r; role; activation; angiotensin ... See more keywords
Long-term interleukin-33 treatment delays disease onset and alleviates astrocytic activation in a transgenic mouse model of amyotrophic lateral sclerosis
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DOI: 10.1016/j.ibror.2019.01.005
Abstract: Highlights • Th2-type cytokine IL-33 delayed the disease onset of female SOD1-G93 A transgenic ALS mice.• IL-33 decreased the proportion of T cells in the spleens and lymph nodes of female mice.• IL-33 decreased astrocytic activation… read more here.
Keywords: long term; treatment; astrocytic activation; disease onset ... See more keywords
Paeonol Ameliorates Chronic Itch and Spinal Astrocytic Activation via CXCR3 in an Experimental Dry Skin Model in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.805222
Abstract: Paeonol is a bioactive phenol presents mainly in Paeonia suffruticosa Andr. (Paeoniaceae), Paeonia lactiflora Pall., and Dioscorea japonica Thunb. (Dioscoreaceae), harboring various pharmacological activities including anti-inflammatory, antioxidant, immune regulatory activity and reverse chemoresistance. Recent reports… read more here.
Keywords: paeonol; expression; astrocytic activation; dry skin ... See more keywords