PV interneurons evoke astrocytic Ca2+ responses in awake mice, which contributes to neurovascular coupling.
Sign Up to like & getrecommendations! Published in 2023 at "Glia"
DOI: 10.1002/glia.24370
Abstract: Neurovascular coupling (NVC) modulates cerebral blood flow to match increased metabolic demand during neuronal excitation. Activation of inhibitory interneurons also increase blood flow, but the basis for NVC caused by interneurons is unclear. While astrocyte… read more here.
Keywords: neurovascular coupling; astrocytic ca2; awake mice; ca2 responses ... See more keywords
Astroglial Ca2+ signaling is generated by the coordination of IP3R and store-operated Ca2+ channels.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.03.096
Abstract: Astrocytes play key roles in the central nervous system and regulate local blood flow and synaptic transmission via intracellular calcium (Ca2+) signaling. Astrocytic Ca2+ signals are generated by multiple pathways: Ca2+ release from the endoplasmic… read more here.
Keywords: store operated; ca2 signaling; astrocytic ca2; ca2 ... See more keywords
Synchronized Astrocytic Ca2+ Responses in Neurovascular Coupling during Somatosensory Stimulation and for the Resting State
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.05.091
Abstract: SUMMARY The role of astrocytes in neurovascular coupling (NVC) is unclear. Here, we applied a multimodality imaging approach to concomitantly measure synchronized neuronal or astrocytic Ca2+ and hemodynamic changes in the mouse somatosensory cortex at… read more here.
Keywords: role astrocytes; stimulation; astrocytic ca2; neurovascular coupling ... See more keywords
Structural basis of astrocytic Ca2+ signals at tripartite synapses
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-15648-4
Abstract: Astrocytic Ca2+ signals can be fast and local, supporting the idea that astrocytes have the ability to regulate single synapses. However, the anatomical basis of such specific signaling remains unclear, owing to difficulties in resolving… read more here.
Keywords: tripartite synapses; astrocytic ca2; ca2 signals; structural basis ... See more keywords
Astrocytic Ca2+ signaling is reduced during sleep and is involved in the regulation of slow wave sleep
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-17062-2
Abstract: Astrocytic Ca2+ signaling has been intensively studied in health and disease but has not been quantified during natural sleep. Here, we employ an activity-based algorithm to assess astrocytic Ca2+ signals in the neocortex of awake… read more here.
Keywords: ca2 signaling; wave sleep; astrocytic ca2; ca2 ... See more keywords
Astrocytic Ca2+ Signaling in Epilepsy
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2021.695380
Abstract: Epilepsy is one of the most common neurological disorders – estimated to affect at least 65 million worldwide. Most of the epilepsy research has so far focused on how to dampen neuronal discharges and to… read more here.
Keywords: ca2 signaling; astrocytic ca2; ca2; brain ... See more keywords