Inhibitions of PKC and CaMK-II synergistically rescue ischemia-induced astrocytic dysfunction
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2017.08.017
Abstract: Ischemic neuronal death is presumably caused by glutamate-induced excitotoxicity, in which the increased glutamate release and impaired glutamate reuptake lead to glutamate accumulation. Mechanisms underlying the ischemic deficiency of astrocytic glutamate reuptake remain unclear, which… read more here.
Keywords: glutamate; astrocytic glutamate; ischemia induced; deficiency ... See more keywords
Astrocyte Glutamate Uptake and Signaling as Novel Targets for Antiepileptogenic Therapy
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2020.01006
Abstract: Astrocytes regulate and respond to extracellular glutamate levels in the central nervous system (CNS) via the Na+-dependent glutamate transporters glutamate transporter-1 (GLT-1) and glutamate aspartate transporter (GLAST) and the metabotropic glutamate receptors (mGluR) 3 and… read more here.
Keywords: astrocyte glutamate; glutamate uptake; metabotropic glutamate; uptake signaling ... See more keywords