Progranulin protects against exaggerated axonal injury and astrogliosis following traumatic brain injury
Sign Up to like & getrecommendations! Published in 2017 at "Glia"
DOI: 10.1002/glia.23091
Abstract: In response to traumatic brain injury (TBI) microglia/macrophages and astrocytes release inflammatory mediators with dual effects on secondary brain damage progression. The neurotrophic and anti‐inflammatory glycoprotein progranulin (PGRN) attenuates neuronal damage and microglia/macrophage activation in… read more here.
Keywords: axonal injury; astrogliosis; brain; mice ... See more keywords
The association of astrogliosis and microglial activation with aging and Alzheimer's disease pathology in the chimpanzee brain
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.25167
Abstract: Aging and neurodegenerative disorders, such as Alzheimer's disease (AD), trigger an immune response known as glial activation in the brain. Recent evidence indicates species differences in inflammatory responses to AD pathology, highlighting the need for… read more here.
Keywords: alzheimer disease; microglial activation; brain; pathology ... See more keywords
Erythropoietin protects the subventricular zone and inhibits reactive astrogliosis in kaolin-induced hydrocephalic rats
Sign Up to like & getrecommendations! Published in 2019 at "Child's Nervous System"
DOI: 10.1007/s00381-019-04063-w
Abstract: PurposeTo elucidate the potential role of erythropoietin (EPO) as a neuroprotective agent against reactive astrogliosis and reducing the thinning rate of subventricular zone (SVZ) in kaolin-induced hydrocephalic rats.MethodThirty-six ten-week-old Sprague-Dawley rats were used in this… read more here.
Keywords: hydrocephalic rats; subventricular zone; reactive astrogliosis; group ... See more keywords
Acute acetaminophen intoxication induces direct neurotoxicity in rats manifested as astrogliosis and decreased dopaminergic markers in brain areas associated with locomotor regulation.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2019.113662
Abstract: Abstract Acetaminophen (APAP) administration at therapeutic doses is safe, however overdosing produces hepatocellular injury via a multifactorial mechanism(s) that involves generation of reactive oxygen species (ROS), being the most common cause of acute liver failure… read more here.
Keywords: intoxication; astrogliosis; brain areas; acute ... See more keywords
Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery
Sign Up to like & getrecommendations! Published in 2019 at "Nature"
DOI: 10.1038/s41586-018-0824-5
Abstract: In addition to maintaining immune tolerance, FOXP3+ regulatory T (Treg) cells perform specialized functions in tissue homeostasis and remodelling1,2. However, the characteristics and functions of brain Treg cells are not well understood because there is… read more here.
Keywords: recovery; treg cells; astrogliosis; brain treg ... See more keywords
Epigallocatechin-3-gallate attenuates acrylamide-induced apoptosis and astrogliosis in rat cerebral cortex
Sign Up to like & getrecommendations! Published in 2017 at "Toxicology Mechanisms and Methods"
DOI: 10.1080/15376516.2017.1279251
Abstract: Abstract The potent neurotoxic agent acrylamide (ACR) is formed during Maillard reaction in food processing. Epigallocatechin-3-gallate (EGCG), a major bioactive component of green tea, is an antioxidant, but its effects on ACR-induced neurotoxicity are unclear.… read more here.
Keywords: apoptosis astrogliosis; cerebral cortex; induced apoptosis; astrogliosis ... See more keywords
Magnetic resonance imaging of neuroinflammation in chronic pain: a role for astrogliosis?
Sign Up to like & getrecommendations! Published in 2020 at "Pain"
DOI: 10.1097/j.pain.0000000000001815
Abstract: Non-invasive measures of neuroinflammatory processes in humans could substantially aid diagnosis and therapeutic development for many disorders, including chronic pain. Several proton Magnetic Resonance Spectroscopy (H-MRS) metabolites have been linked with glial activity (i.e. choline… read more here.
Keywords: choline; astrogliosis; anterior insula; chronic pain ... See more keywords
Reactive astrogliosis: A friend or foe in the pathogenesis of Alzheimer's disease.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of neurochemistry"
DOI: 10.1111/jnc.15565
Abstract: Astrocytes are highly efficient homeostatic glial cells playing a crucial role in the optimal brain functioning and homeostasis. Astrocytes respond to changes in brain homoeostasis following central nervous system (CNS) injury/diseased state by a specific… read more here.
Keywords: brain; reactive astrogliosis; astrogliosis friend; astrogliosis ... See more keywords
Transcranial photobiomodulation (808 nm) attenuates pentylenetetrazole-induced seizures by suppressing hippocampal neuroinflammation, astrogliosis, and microgliosis in peripubertal rats
Sign Up to like & getrecommendations! Published in 2022 at "Neurophotonics"
DOI: 10.1117/1.nph.9.1.015006
Abstract: Abstract. Significance: Transcranial photobiomodulation (tPBM) at 808 nm attenuates pentylenetetrazole (PTZ)-induced seizures and convulsive status epilepticus (CSE) in peripubertal rats by protecting neurons from injury and parvalbumin-positive interneurons from apoptosis, and preserving the integrity of… read more here.
Keywords: peripubertal rats; astrogliosis; induced seizures; microgliosis ... See more keywords
Transforming growth factor-β1 induces cerebrovascular dysfunction and astrogliosis through angiotensin II type 1 receptor-mediated signaling pathways.
Sign Up to like & getrecommendations! Published in 2018 at "Canadian journal of physiology and pharmacology"
DOI: 10.1139/cjpp-2017-0640
Abstract: Transgenic mice constitutively overexpressing the cytokine transforming growth factor-β1 (TGF-β1) (TGF mice) display cerebrovascular alterations as seen in Alzheimer's disease (AD) and vascular cognitive impairment and dementia (VCID), but no or only subtle cognitive deficits.… read more here.
Keywords: growth factor; tgf; astrogliosis; mice ... See more keywords
Reactive Astrogliosis: Implications in Spinal Cord Injury Progression and Therapy
Sign Up to like & getrecommendations! Published in 2020 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2020/9494352
Abstract: Astrocytes are the most populous glial cells in the central nervous system (CNS). They are essential to CNS physiology and play important roles in the maintenance of homeostasis, development of synaptic plasticity, and neuroprotection. Nevertheless,… read more here.
Keywords: astrogliosis implications; reactive astrogliosis; astrogliosis; cord injury ... See more keywords