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   Articles with "asxl1" as a keyword



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Clonal myelopoiesis in the UK Biobank cohort: ASXL1 mutations are strongly associated with smoking

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recommendations! Published in 2020 at "Leukemia"

DOI: 10.1038/s41375-020-0896-8

Abstract: We sought to determine the significance of myeloid clonal hematopoiesis (CH) in the UK Biobank cohort ( n  = 502,524, median age = 58 years). Utilizing SNP array ( n  = 486,941) and whole exome sequencing data ( n… read more here.

Keywords: asxl1; smoking; biobank cohort; strongly associated ... See more keywords
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ASXL1 frameshift mutations drive inferior outcomes in CMML without negative impact in MDS

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recommendations! Published in 2017 at "Blood Cancer Journal"

DOI: 10.1038/s41408-017-0004-0

Abstract: Next-generation sequencing (NGS) has revolutionized the diagnostic, prognostic and treatment paradigms in myeloid malignancies. Although somatic mutations can be identified in the majority of patients with myelodysplastic syndromes (MDS) and chronic myelomonocytic leukemia (CMML), the… read more here.

Keywords: asxl1; impact; significance; mds ... See more keywords
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CHIP‐associated mutant ASXL1 in blood cells promotes solid tumor progression

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recommendations! Published in 2022 at "Cancer Science"

DOI: 10.1111/cas.15294

Abstract: Clonal hematopoiesis of indeterminate potential (CHIP) is an age‐associated phenomenon characterized by clonal expansion of blood cells harboring somatic mutations in hematopoietic genes, including DNMT3A, TET2, and ASXL1. Clinical evidence suggests that CHIP is highly… read more here.

Keywords: solid tumor; asxl1; chip; blood cells ... See more keywords
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Cooperative Epigenetic Regulation By ASXL1 and NF1 Loss on Leukemogenesis

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recommendations! Published in 2018 at "Blood"

DOI: 10.1182/blood-2018-99-110964

Abstract: Introduction: Additional sex combs-like 1 (ASXL1) is frequently mutated in a wide range of myeloid malignancies, including myelodysplastic syndrome (MDS), myeloproliferative neoplasm, chronic myelomonocytic leukemia, and acute myeloid leukemia (AML). Notably, ASXL1 mutations are generally… read more here.

Keywords: asxl1; asxl1 nf1; mice; myeloid ... See more keywords
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Mutant ASXL1 Disrupts Paraspeckle Formation through Aberrant Interaction with Nono in Hematopoietic Cells

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recommendations! Published in 2019 at "Blood"

DOI: 10.1182/blood-2019-125472

Abstract: Paraspeckles are sub-nuclear structures found in the interchromatin space of mammalian cells. The core paraspeckle components include a lncRNA NEAT1 and members of the DBHS family of proteins: NONO, SFPQ, and PSPC1. Paraspeckles and their… read more here.

Keywords: asxl1 hspcs; mutant asxl1; asxl1; paraspeckle formation ... See more keywords
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Leukemogenic Functions of Mutant ASXL1 Are Regulated By CDK-Mediated Phosphorylation

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recommendations! Published in 2019 at "Blood"

DOI: 10.1182/blood-2019-125959

Abstract: Additional sex combs-like 1 (ASXL1) is recurrently mutated in various myeloid neoplasms and its mutations confer poor prognosis. Most of the ASXL1 mutations in myeloid malignancies are frameshift or nonsense mutations, leading to expression of… read more here.

Keywords: asxl1; cdk mediated; leukemogenic functions; phosphorylation ... See more keywords
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ASXL1 Mutations Are Associated with Widespread and Distinct DNA Methylation Alterations

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recommendations! Published in 2019 at "Blood"

DOI: 10.1182/blood-2019-126850

Abstract: Background: ASXL1 is frequently mutated in a range of myeloid malignancies, including MDS, CMML, and AML, and is strongly associated with a poor prognosis in these myeloid disorders. ASXL1 is known to play a central… read more here.

Keywords: asxl1; methylation; expression; gene ... See more keywords
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Modeling ASXL1 Mutation Revealed Myelodysplasia Caused By Derepression of p16Ink4a through Aberrant PRC1-Mediated Histone Modification

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recommendations! Published in 2017 at "Blood"

DOI: 10.1182/blood.v130.suppl_1.118.118

Abstract: Clonal hematopoiesis of indeterminate potential (CHIP) is a premalignant condition in patients with blood cells that possess somatic mutations of genes known to be recurrently mutated in hematologic malignancies. Among them is additional sex combs… read more here.

Keywords: asxl1g643fs mice; asxl1; p16ink4a; mice ... See more keywords