The role of ASXL1 in hematopoiesis and myeloid malignancies
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-019-03084-7
Abstract: Recent high-throughput genome-wide sequencing studies have identified recurrent somatic mutations in myeloid neoplasms. An epigenetic regulator, Additional sex combs-like 1 (ASXL1), is one of the most frequently mutated genes in all subtypes of myeloid malignancies.… read more here.
Keywords: role; myeloid malignancies; asxl1 mutations; hematopoiesis ... See more keywords
Prognostic value of ASXL1 mutations in patients with primary myelofibrosis and its relationship with clinical features: a meta-analysis
Sign Up to like & getrecommendations! Published in 2021 at "Annals of Hematology"
DOI: 10.1007/s00277-020-04387-7
Abstract: Additional sex combs like 1 (ASXL1) mutations are one of the most common molecular biological abnormalities in patients with primary myelofibrosis (PMF), and the effect of these mutations on prognosis remains controversial. Hence, we conducted… read more here.
Keywords: primary myelofibrosis; prognostic value; asxl1 mutations; patients primary ... See more keywords
Pathological ASXL1 Mutations and Protein Variants Impair Neural Crest Development
Sign Up to like & getrecommendations! Published in 2019 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2019.03.006
Abstract: Summary The neural crest (NC) gives rise to a multitude of fetal tissues, and its misregulation is implicated in congenital malformations. Here, we investigated molecular mechanisms pertaining to NC-related symptoms in Bohring-Opitz syndrome (BOS), a… read more here.
Keywords: pathological asxl1; stem cell; asxl1 mutations; truncated asxl1 ... See more keywords
Evaluating the frequency, prognosis and survival of RUNX1 and ASXL1 mutations in patients with acute myeloid leukaemia in northeastern Iran
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17424
Abstract: To evaluate the frequency and prognosis of runt‐related transcription factor 1 (RUNX1) and additional sex combs like‐1 (ASXL1) mutations in acute myeloid leukaemia (AML) patients in northeastern Iran. This cross‐sectional study was performed on 40… read more here.
Keywords: runx1; prognosis; survival; frequency ... See more keywords
Prognostic value of ASXL1 mutations in patients with myelodysplastic syndromes and acute myeloid leukemia: A meta-analysis.
Sign Up to like & getrecommendations! Published in 2022 at "Asia-Pacific journal of clinical oncology"
DOI: 10.37766/inplasy2022.4.0013
Abstract: Additional sex combs-like 1 (ASXL1) mutations, a hotspot in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), have been frequently reported for their potential prognostic value, but the results are controversial. Therefore, a meta-analysis was… read more here.
Keywords: myeloid leukemia; meta analysis; asxl1 mutations; acute myeloid ... See more keywords