Chiral Brønsted Acid‐Catalyzed Asymmetric 1,4‐Addition of Benzofuran‐Derived Azadienes with 3‐Substituted indoles
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DOI: 10.1002/cctc.202000810
Abstract: A chiral phosphoric acid‐catalyzed asymmetric 1,4‐addition of benzofuran‐derived azadienes with 3‐substituted indoles has been established, which offered enantioenriched tri(hetero)arylmethane products in generally good yields (up to 98 %) and high enantioselectivities (up to 99 : 1 er). This reaction… read more here.
Keywords: derived azadienes; catalyzed asymmetric; benzofuran derived; acid catalyzed ... See more keywords
Catalytic Asymmetric Addition Reactions of Formaldehyde N,N-Dialkylhydrazone to Synthesize Chiral Nitrile Derivatives.
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DOI: 10.1021/acs.orglett.0c01857
Abstract: A number of nitrile-containing chiral molecules were synthesized via asymmetric nucleophilic addition of formaldehyde N,N-dialkylhydrazone as the nitrile equivalent. Chiral N,N'-dioxide/metal salt complexes enabled the asymmetric addition reactions to both isatin-derived imines and α,β-unsaturated ketones,… read more here.
Keywords: formaldehyde dialkylhydrazone; addition; asymmetric addition; addition reactions ... See more keywords
Asymmetric Addition of α-Diazomethylphosphonate to Alkylideneindolenine Catalyzed by a Trifunctional BINAP-Based Monophosphonium Salt.
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DOI: 10.1021/acs.orglett.2c00213
Abstract: A series of trifunctional BINAP-based monophosphonium phase-transfer catalysts were developed and used in the asymmetric addition of α-diazomethylphosphonates to vinylogous imines formed in situ from sulfonylindoles. This methodology tolerates a broad scope of 2-unsubstituted sulfonyl… read more here.
Keywords: based monophosphonium; trifunctional binap; asymmetric addition; binap based ... See more keywords
Rhodium-catalyzed asymmetric 1,4-addition reactions of aryl boronic acids with nitroalkenes: reaction mechanism and development of homogeneous and heterogeneous catalysts† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc03025h
Sign Up to like & getrecommendations! Published in 2017 at "Chemical Science"
DOI: 10.1039/c7sc03025h
Abstract: Asymmetric 1,4-additions of arylboronic acids with nitroalkenes catalyzed by rhodium complexes or heterogeneous Rh–Ag bimetallic nanoparticles with a chiral diene ligand bearing a tertiary butyl amide moiety are developed. read more here.
Keywords: catalyzed asymmetric; rhodium; rhodium catalyzed; asymmetric addition ... See more keywords
Asymmetric addition of Grignard reagents to ketones: culmination of the ligand-mediated methodology allows modular construction of chiral tertiary alcohols
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DOI: 10.1039/d1sc06350b
Abstract: A new class of biaryl chiral ligands derived from 1,2-diaminocyclohexane (1,2-DACH) has been designed to enable the asymmetric addition of aliphatic and, for the first time, aromatic Grignard reagents to ketones for the preparation of… read more here.
Keywords: grignard reagents; methodology; asymmetric addition; reagents ketones ... See more keywords
Asymmetric addition of an N-methyl C(sp3)-H bond to cyclic alkenes enabled by an iridium/phosphine-olefin catalyst.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc04642c
Abstract: Iridium-catalyzed asymmetric C-H addition of an N-methyl group on 3-trifluoromethyl-2-(N-methylamino)pyridine to cyclic alkenes was realized by using a phosphine-olefin ligand. Indene and its 7-substituted derivatives, acenaphthylene, and some bicyclic alkenes underwent the addition to give… read more here.
Keywords: phosphine olefin; addition; asymmetric addition; addition methyl ... See more keywords
Palladium-Catalyzed Asymmetric 1,4-Addition of Diarylphosphines to α,β-Unsaturated Sulfonyl Fluorides
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DOI: 10.1055/a-2067-7071
Abstract: A Pd-catalyzed asymmetric phosphination of α, β-unsaturated sulfonyl fluorides was developed, and a series of tertiary phosphorus compounds were obtained in excellent yields and enantioselectivities (up to 99% ee). The chiral adduct can be further… read more here.
Keywords: unsaturated sulfonyl; palladium catalyzed; asymmetric addition; catalyzed asymmetric ... See more keywords
Palladium-Catalyzed Asymmetric 1,4-Addition of Diarylphosphines to α,β-Unsaturated Sulfonamides
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DOI: 10.1055/s-0036-1591593
Abstract: A pincer palladium-catalyzed asymmetric 1,4-addition of diarylphosphines to α,β-unsaturated sulfonamides was realized for the synthesis of chiral sulfonamide phosphines with up to 98% ee under mild conditions. read more here.
Keywords: catalyzed asymmetric; unsaturated sulfonamides; diarylphosphines unsaturated; palladium catalyzed ... See more keywords
Ru-Catalyzed Asymmetric Addition of Arylboronic Acids to Aliphatic Aldehydes via P-Chiral Monophosphorous Ligands
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DOI: 10.3390/molecules27123898
Abstract: Chiral alcohols are among the most widely applied in fine chemicals, pharmaceuticals and agrochemicals. Herein, the Ru-monophosphine catalyst formed in situ was found to promote an enantioselective addition of aliphatic aldehydes with arylboronic acids, delivering… read more here.
Keywords: aliphatic aldehydes; monophosphorous ligands; asymmetric addition; catalyzed asymmetric ... See more keywords