Catalytic Asymmetric [3 + 2] Annulation of Hantzsch Esters with Racemic N-Sulfonylaziridines.
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DOI: 10.1021/acs.orglett.1c02931
Abstract: Hantzsch esters (HEs) served as two-carbon partners in a copper(I)-catalyzed enantioselective [3 + 2] annulation with racemic 2-(hetero)aryl-N-sulfonyl aziridines via kinetic resolution to provide pyrrolo[2,3-b]tetrahydropyridines containing multiple contiguous stereogenic centers including all-carbon quaternary centers in… read more here.
Keywords: annulation hantzsch; asymmetric annulation; hantzsch esters; hantzsch ... See more keywords
Asymmetric [3 + 3] Annulation of Copper-Allenylidenes with Pyrazolones: Synthesis of Chiral 1,4-Dihydropyrano[2,3- c]pyrazoles.
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DOI: 10.1021/acs.orglett.8b02214
Abstract: The copper-catalyzed asymmetric [3 + 3] annulation of ethynyl benzoxazinanones with pyrazolones has been achieved, providing simple access to 1,4-dihydropyrano[2,3- c]pyrazole derivatives in moderate to excellent yields with excellent enantioselectivities (up to 99% ee). Compared… read more here.
Keywords: dihydropyrano; annulation; copper allenylidenes; annulation copper ... See more keywords