Regulation of Asymmetric Cell Division in Mammalian Neural Stem and Cancer Precursor Cells.
Sign Up to like & getrecommendations! Published in 2017 at "Results and problems in cell differentiation"
DOI: 10.1007/978-3-319-53150-2_17
Abstract: Stem and progenitor cells are characterized by their abilities to self-renew and produce differentiated progeny. The balance between self-renewal and differentiation is achieved through control of cell division mode, which can be either asymmetric or… read more here.
Keywords: asymmetric cell; cell division; cancer; stem ... See more keywords
Fat3 acts through independent cytoskeletal effectors to coordinate asymmetric cell behaviors during polarized circuit assembly
Sign Up to like & getrecommendations! Published in 2022 at "Cell reports"
DOI: 10.1016/j.celrep.2022.110307
Abstract: SUMMARY The polarized flow of information through neural circuits depends on the orderly arrangement of neurons, their processes, and their synapses. This polarity emerges sequentially in development, starting with the directed migration of neuronal precursors,… read more here.
Keywords: coordinate asymmetric; cell behaviors; fat3 acts; asymmetric cell ... See more keywords
A spatiotemporal molecular switch governs plant asymmetric cell division.
Sign Up to like & getrecommendations! Published in 2021 at "Nature plants"
DOI: 10.1038/s41477-021-00906-0
Abstract: Asymmetric cell division (ACD) requires protein polarization in the mother cell to produce daughter cells with distinct identities (cell-fate asymmetry). Here, we define a previously undocumented mechanism for establishing cell-fate asymmetry in Arabidopsis stomatal stem… read more here.
Keywords: asymmetric cell; division; polarization; cell division ... See more keywords
Inducible asymmetric cell division and cell differentiation in a bacterium
Sign Up to like & getrecommendations! Published in 2019 at "Nature chemical biology"
DOI: 10.1038/s41589-019-0340-4
Abstract: Multicellular organisms achieve greater complexity through cell divisions that generate different cell types. We engineered a simple genetic circuit that induces asymmetric cell division and subsequent cell differentiation in Escherichia coli. The circuit involves a… read more here.
Keywords: asymmetric cell; cell differentiation; cell division; biology ... See more keywords
Polarized endosome dynamics engage cytoplasmic Par-3 that recruits dynein during asymmetric cell division
Sign Up to like & getrecommendations! Published in 2021 at "Science Advances"
DOI: 10.1126/sciadv.abg1244
Abstract: In vivo imaging and expansion microscopy reveal a new role of cytosolic Par-3 in polarized transport of Notch signaling endosome. In the developing embryos, the cortical polarity regulator Par-3 is critical for establishing Notch signaling… read more here.
Keywords: asymmetric cell; par; microscopy; cytoplasmic par ... See more keywords
Design and Characterization of Asymmetric Cell Structure of Auxetic Material for Predictable Directional Mechanical Response
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DOI: 10.3390/ma15051841
Abstract: A three-dimensional auxetic structure based on a known planar configuration including a design parameter producing asymmetry is proposed in this study. The auxetic cell is designed by topology analysis using classical Timoshenko beam theory in… read more here.
Keywords: cell structure; cell; structure; asymmetric cell ... See more keywords
Activation of Discs large by aPKC aligns the mitotic spindle to the polarity axis during asymmetric cell division
Sign Up to like & getrecommendations! Published in 2017 at "eLife"
DOI: 10.7554/elife.32137
Abstract: Asymmetric division generates cellular diversity by producing daughter cells with different fates. In animals, the mitotic spindle aligns with Par complex polarized fate determinants, ensuring that fate determinant cortical domains are bisected by the cleavage… read more here.
Keywords: asymmetric cell; division; cell division; polarity ... See more keywords
Regulated spindle orientation buffers tissue growth in the epidermis
Sign Up to like & getrecommendations! Published in 2019 at "eLife"
DOI: 10.7554/elife.48482
Abstract: Tissue homeostasis requires a balance between progenitor cell proliferation and loss. Mechanisms that maintain this robust balance are needed to avoid tissue loss or overgrowth. Here we demonstrate that regulation of spindle orientation/asymmetric cell divisions… read more here.
Keywords: orientation; cell divisions; asymmetric cell; spindle orientation ... See more keywords