Regulation of Asymmetric Cell Division in Mammalian Neural Stem and Cancer Precursor Cells.
Sign Up to like & getrecommendations! Published in 2017 at "Results and problems in cell differentiation"
DOI: 10.1007/978-3-319-53150-2_17
Abstract: Stem and progenitor cells are characterized by their abilities to self-renew and produce differentiated progeny. The balance between self-renewal and differentiation is achieved through control of cell division mode, which can be either asymmetric or… read more here.
Keywords: asymmetric cell; cell division; cancer; stem ... See more keywords
Fat3 acts through independent cytoskeletal effectors to coordinate asymmetric cell behaviors during polarized circuit assembly
Sign Up to like & getrecommendations! Published in 2022 at "Cell reports"
DOI: 10.1016/j.celrep.2022.110307
Abstract: SUMMARY The polarized flow of information through neural circuits depends on the orderly arrangement of neurons, their processes, and their synapses. This polarity emerges sequentially in development, starting with the directed migration of neuronal precursors,… read more here.
Keywords: coordinate asymmetric; cell behaviors; fat3 acts; asymmetric cell ... See more keywords
The replicative helicase CMG is required for the divergence of cell fates during asymmetric cell division in vivo
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-53715-2
Abstract: The mechanisms that enable differential gene expression in daughter cells produced by asymmetric cell divisions are not well understood. We discovered that the eukaryotic replicative helicase CMG (Cdc45-MCM-GINS) is required for this process in C.… read more here.
Keywords: replicative helicase; cell; cell division; cmg ... See more keywords
Glucose-6-phosphate-dehydrogenase on old peroxisomes maintains self-renewal of epithelial stem cells after asymmetric cell division
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-58752-z
Abstract: Selective inheritance of sub-cellular components has emerged as a mechanism guiding stem cell fate after asymmetric cell divisions. Peroxisomes play a crucial role in multiple metabolic processes such as fatty acid metabolism and reactive oxygen… read more here.
Keywords: stem cell; stem; cell; cell division ... See more keywords
A spatiotemporal molecular switch governs plant asymmetric cell division.
Sign Up to like & getrecommendations! Published in 2021 at "Nature plants"
DOI: 10.1038/s41477-021-00906-0
Abstract: Asymmetric cell division (ACD) requires protein polarization in the mother cell to produce daughter cells with distinct identities (cell-fate asymmetry). Here, we define a previously undocumented mechanism for establishing cell-fate asymmetry in Arabidopsis stomatal stem… read more here.
Keywords: asymmetric cell; division; polarization; cell division ... See more keywords
Inducible asymmetric cell division and cell differentiation in a bacterium
Sign Up to like & getrecommendations! Published in 2019 at "Nature chemical biology"
DOI: 10.1038/s41589-019-0340-4
Abstract: Multicellular organisms achieve greater complexity through cell divisions that generate different cell types. We engineered a simple genetic circuit that induces asymmetric cell division and subsequent cell differentiation in Escherichia coli. The circuit involves a… read more here.
Keywords: asymmetric cell; cell differentiation; cell division; biology ... See more keywords
Human RAP2A homolog of the Drosophila asymmetric cell division regulator Rap2l targets the stemness of glioblastoma stem cells
Sign Up to like & getrecommendations! Published in 2025 at "eLife"
DOI: 10.1101/2025.01.28.635292
Abstract: Asymmetric cell division (ACD) is a fundamental process to balance cell proliferation and differentiation during development and in the adult. Cancer stem cells (CSCs), a very small but highly malignant population within many human tumors,… read more here.
Keywords: stem; stem cells; cell; cell division ... See more keywords
Polarized endosome dynamics engage cytoplasmic Par-3 that recruits dynein during asymmetric cell division
Sign Up to like & getrecommendations! Published in 2021 at "Science Advances"
DOI: 10.1126/sciadv.abg1244
Abstract: In vivo imaging and expansion microscopy reveal a new role of cytosolic Par-3 in polarized transport of Notch signaling endosome. In the developing embryos, the cortical polarity regulator Par-3 is critical for establishing Notch signaling… read more here.
Keywords: asymmetric cell; par; microscopy; cytoplasmic par ... See more keywords
Quantitative perturbation-phenotype maps reveal nonlinear responses underlying robustness of PAR-dependent asymmetric cell division
Sign Up to like & getrecommendations! Published in 2024 at "PLOS Biology"
DOI: 10.1371/journal.pbio.3002437
Abstract: A key challenge in the development of an organism is to maintain robust phenotypic outcomes in the face of perturbation. Yet, it is often unclear how such robust outcomes are encoded by developmental networks. Here,… read more here.
Keywords: robustness par; dependent asymmetric; perturbation; division ... See more keywords
Design and Characterization of Asymmetric Cell Structure of Auxetic Material for Predictable Directional Mechanical Response
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DOI: 10.3390/ma15051841
Abstract: A three-dimensional auxetic structure based on a known planar configuration including a design parameter producing asymmetry is proposed in this study. The auxetic cell is designed by topology analysis using classical Timoshenko beam theory in… read more here.
Keywords: cell structure; cell; structure; asymmetric cell ... See more keywords
Activation of Discs large by aPKC aligns the mitotic spindle to the polarity axis during asymmetric cell division
Sign Up to like & getrecommendations! Published in 2017 at "eLife"
DOI: 10.7554/elife.32137
Abstract: Asymmetric division generates cellular diversity by producing daughter cells with different fates. In animals, the mitotic spindle aligns with Par complex polarized fate determinants, ensuring that fate determinant cortical domains are bisected by the cleavage… read more here.
Keywords: asymmetric cell; division; cell division; polarity ... See more keywords