De Novo Construction of Chiral Aminoindolines by Cu-Catalyzed Asymmetric Cyclization and Subsequent Discovery of an Unexpected Sulfonyl Migration.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c08090
Abstract: Searching for efficient strategies to access structurally novel aminoindolines is of great significance for drug discovery. However, catalytic asymmetric de novo construction of aminoindoline scaffolds with functionality primed for diversification still remains elusive. Here, we… read more here.
Keywords: chiral aminoindolines; sulfonyl migration; catalyzed asymmetric; novo construction ... See more keywords
Copper-catalyzed asymmetric cyclization of alkenyl diynes: method development and new mechanistic insightsâ€
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DOI: 10.1039/d1sc02773e
Abstract: Metal carbenes have proven to be one of the most important and useful intermediates in organic synthesis, but catalytic asymmetric reactions involving metal carbenes are still scarce and remain a challenge. Particularly, the mechanistic pathway… read more here.
Keywords: copper; catalyzed asymmetric; cyclization alkenyl; asymmetric cyclization ... See more keywords