Pd-Catalyzed Asymmetric Dearomative Arylation of Indoles via a Desymmetrization Strategy.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c00129
Abstract: Pd-catalyzed asymmetric dearomative arylation of C3-substituted indoles is realized via a desymmetrization strategy. A BINOL-derived chiral phosphoramidite ligand is found to be highly efficient for the stereoselective control in this reaction. This method provides a… read more here.
Keywords: dearomative arylation; catalyzed asymmetric; desymmetrization strategy; via desymmetrization ... See more keywords
Palladium-Catalyzed Asymmetric Dearomative Carbonylation of Indoles.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c00962
Abstract: Herein, we disclose a strategy for the asymmetric dearomatization of N-arylacyl indoles via a palladium-catalyzed tandem Heck/carbonylation, leading to an array of indoline-3-carboxylates bearing vicinal C2-aza-quaternary and C3 tertiary stereocenters in high yields and excellent… read more here.
Keywords: dearomative carbonylation; carbonylation; palladium catalyzed; carbonylation indoles ... See more keywords
Divergent and Enantioselective Synthesis of Three Types of Chiral Polycyclic N‑Heterocycles via Copper-Catalyzed Dearomative Cyclization
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DOI: 10.1021/acscentsci.5c00248
Abstract: Significant advancements have been made in the catalytic asymmetric dearomatization of indoles for constructing valuable chiral polycyclic N-heterocycles. However, the asymmetric dearomative cyclopropanation of indoles continues to pose a formidable challenge. Furthermore, the diverse transformations… read more here.
Keywords: dearomative cyclopropanation; divergent enantioselective; asymmetric dearomative; synthesis ... See more keywords
Asymmetric Dearomative [2 + 2] Photocycloaddition of Quinoline and Indole Derivatives with Bicyclo[1.1.0]butanes.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.5c12057
Abstract: The dearomative photocycloaddition reactions of (hetero)arene feedstocks have emerged as an efficient platform for the construction of three-dimensional complexity, which is of increasing interest in medicinal chemistry. Nevertheless, the catalytic asymmetric version of such transformations… read more here.
Keywords: dearomative photocycloaddition; asymmetric dearomative; bicyclo butanes; regio diastereo ... See more keywords
Copper-catalyzed asymmetric dearomative alkynylation of isoquinolines
Sign Up to like & getrecommendations! Published in 2020 at "Organic chemistry frontiers"
DOI: 10.1039/d0qo00041h
Abstract: Cu/(Ph-pybox)-catalyzed asymmetric dearomative alkynylation of isoquinolines has been realized in high to excellent enantioselectivities (up to 96% ee) with α-bromoacetophenone as an activator and 1,1′-binaphthyl-2,2′-diyl hydrogenphosphate as an additive. This novel reaction tolerates a wide… read more here.
Keywords: dearomative alkynylation; catalyzed asymmetric; alkynylation isoquinolines; asymmetric dearomative ... See more keywords
Asymmetric dearomative cyclopropanation of naphthalenes to construct polycyclic compounds
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DOI: 10.1039/d2sc04509e
Abstract: Catalytic asymmetric dearomatization (CADA) reactions is an important synthetic method for constructing enantioenriched complex cyclic systems from simple aromatic feedstocks. However, the CADA reactions of nonactivated arenes, such as naphthalenes and benzenes, have been far… read more here.
Keywords: cyclopropanation naphthalenes; naphthalenes construct; cyclopropanation; polycyclic compounds ... See more keywords
Copper-catalyzed asymmetric dearomative borylation: new pathway to optically active heterocyclic compounds
Sign Up to like & getrecommendations! Published in 2018 at "Pure and Applied Chemistry"
DOI: 10.1515/pac-2017-0912
Abstract: Abstract Chiral N-heterocyclic organoboronates represent promising intermediates for the preparation of various bioactive and pharmaceutical compounds. We recently reported the first asymmetric dearomative borylation of indoles by copper-catalyzed borylation. Then we further developed dearomatization/enantioselective borylation… read more here.
Keywords: enantioselective borylation; borylation; asymmetric dearomative; dearomative borylation ... See more keywords