Palladium-Catalyzed Asymmetric Desymmetrization for the Simultaneous Construction of Chiral Phosphorus and Quaternary Carbon Stereocenters.
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DOI: 10.1021/acs.orglett.4c01863
Abstract: A palladium-catalyzed asymmetric tandem Heck and carbonylation of bisallyl-phosphine oxides has been developed. This desymmetrization process provided an efficient route to the simultaneous synthesis of a chiral P-stereogenic center and a chiral quaternary carbon stereocenter… read more here.
Keywords: catalyzed asymmetric; asymmetric desymmetrization; palladium catalyzed; quaternary carbon ... See more keywords
Enantioselective Synthesis of Hydrindanes via Palladium-Catalyzed Asymmetric Desymmetrization of Cyclohexadiene Derivatives.
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DOI: 10.1021/acs.orglett.4c04733
Abstract: We herein disclose a strategy for the asymmetric desymmetrization of cyclohexadiene derivatives via a palladium-catalyzed Heck and tandem Heck/Tsuji-Trost allylic alkoxylation reaction. By employing DCE as the solvent, we obtained a variety of chiral hydrindanes… read more here.
Keywords: palladium catalyzed; desymmetrization cyclohexadiene; asymmetric desymmetrization; cyclohexadiene derivatives ... See more keywords