Gold Catalysis, Asymmetric Friedel-Crafts Alkylation Cascade for One-Pot Synthesis of Chiral Dihydrocarbazoles and Dihydrodibenzofurans.
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DOI: 10.1021/acs.orglett.4c00311
Abstract: A one-pot gold-catalyzed acyl migration followed by ytterbium-catalyzed asymmetric Friedel-Crafts alkylation is disclosed, leading to the rapid synthesis of chiral dihydrocarbazoles and dihydrodibenzofuran in generally moderate to good overall yields with good to excellent enantioselectivities.… read more here.
Keywords: crafts alkylation; asymmetric friedel; friedel crafts; one pot ... See more keywords
Protonated Bis-1,2,3-triazole as an Anion-Binding Chiral Brønsted Acid for Catalytic Asymmetric Friedel–Crafts Reaction of Indoles with Imines
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DOI: 10.1246/bcsj.20180098
Abstract: The complex of chiral C2-symmetric bis-1,2,3-triazole and an achiral Bronsted acid is introduced as a new class of chiral acid catalysts. The catalytic activity and stereocontrolling ability of this chiral Bronsted acid can be tuned… read more here.
Keywords: reaction indoles; asymmetric friedel; crafts reaction; bis triazole ... See more keywords
Asymmetric Friedel–Crafts Alkylation of Indoles Catalyzed by Chiral Aziridine-Phosphines
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DOI: 10.3390/catal10090971
Abstract: Over the course of the present studies, a series of optically pure phosphines functionalized by chiral aziridines was synthesized in reasonable/good chemical yields. Their catalytic activity was checked in the enantioselective Friedel–Crafts alkylation of indoles… read more here.
Keywords: crafts alkylation; alkylation indoles; asymmetric friedel; indoles catalyzed ... See more keywords