The Stereoselective Total Synthesis of Axially Chiral Naphthylisoquinoline Alkaloids.
Sign Up to like & getrecommendations! Published in 2022 at "Accounts of chemical research"
DOI: 10.1021/acs.accounts.2c00432
Abstract: ConspectusThe naphthylisoquinoline (NIQ) alkaloids are a thrilling class of natural biaryls─structurally, biosynthetically, and pharmacologically. A common feature of these metabolites is the biaryl bond between their naphthalene and isoquinoline moieties, which in most cases is… read more here.
Keywords: asymmetric induction; biaryl; synthesis; total synthesis ... See more keywords
Asymmetric Induction with a Chiral Amine Catalyzed by a Ru-PNP Pincer Complex: Insight from Theoretical Investigation.
Sign Up to like & getrecommendations! Published in 2020 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.0c00823
Abstract: In this paper, the mechanism of asymmetric amination of a racemic alcohol with Ellman's sulfinamide and the origin of diastereoselectivity catalyzed by a Ru-PNP pincer complex were studied using density functional theory (DFT). The mechanism… read more here.
Keywords: pincer complex; catalyzed pnp; induction chiral; pnp pincer ... See more keywords
Asymmetric Induction via the Structural Indenyl Effect
Sign Up to like & getrecommendations! Published in 2018 at "Organometallics"
DOI: 10.1021/acs.organomet.7b00841
Abstract: Constrained geometry, planar chiral, dichloro[η5:κS-indenyl-sulfanyl]rhodium complex (pS)-1 reacts with (E)-2-pentene in the presence of silver hexafluoroantimonate to afford syn,syn-1,3-dimethyl-π-allyl complex (pS)-2 in 88% yield. Reaction of (pS)-2 with the sodium or tetrabutylammonium salts of dimethyl… read more here.
Keywords: indenyl effect; via structural; structural indenyl; asymmetric induction ... See more keywords
Remote Asymmetric Induction Using Acetate-Type Vinylketene Silyl N,O-Acetals.
Sign Up to like & getrecommendations! Published in 2017 at "Organic letters"
DOI: 10.1021/acs.orglett.6b03476
Abstract: Remote asymmetric induction by the vinylogous Mukaiyama aldol reaction using the acetate-type vinylketene silyl N,O-acetal possessing a chiral auxiliary has been achieved. The silyl N,O-acetal derived from crotonate and l-valine afforded the O-silylated 5R- and… read more here.
Keywords: using acetate; acetate type; asymmetric induction; vinylketene silyl ... See more keywords
Mimicking Enzymes: Asymmetric Induction inside a Carbamate-Based Steroidal Cleft.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b01170
Abstract: Cholic acid has been elaborated into a carbamate-based tripodal architecture, which is able to promote an asymmetric organic transformation inside its chiral cavity. The nature of this steroidal catalyst has been disclosed by quantum-chemical calculations.… read more here.
Keywords: induction inside; enzymes asymmetric; carbamate based; asymmetric induction ... See more keywords
Sigma-Bond Metathesis as an Unusual Asymmetric Induction Step in Rhodium-Catalyzed Enantiodivergent Synthesis of C-N Axially Chiral Biaryls.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.3c00003
Abstract: Mechanistic understanding of asymmetric induction plays a crucial role in designing new catalytic asymmetric reactions. Reported herein is atroposelective access to C-N axially chiral isoquinolones via rhodium-catalyzed C-H activation of N-alkoxy benzamides and annulation with… read more here.
Keywords: bond metathesis; asymmetric induction; rhodium;
Preparation of enantioenriched helical- and axial-chiral molecules by dynamic asymmetric induction.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d1cc05881a
Abstract: Dynamic asymmetric induction (DYASIN) of racemic dynamic chiral heterohelicenes afforded their highly enantioenriched forms (up to 96% ep) in quantitative yields. These heterohelicenes were readily converted into semi-static axial-chiral 1,1'-binaphthyl derivatives in a stereospecific manner. read more here.
Keywords: enantioenriched helical; preparation enantioenriched; dynamic asymmetric; asymmetric induction ... See more keywords
Asymmetric Induction and Amplification in Stereodynamic Catalytic Systems by Noncovalent Interactions
Sign Up to like & getrecommendations! Published in 2020 at "Synlett"
DOI: 10.1055/a-1274-2777
Abstract: The local transmission of chiral information by noncovalent interactions is one of the most fundamental processes broadly found in nature, i.e. in complex biochemical systems. This review summarizes our accomplishments in investigating chiral induction in… read more here.
Keywords: induction amplification; noncovalent interactions; asymmetric induction; chiral induction ... See more keywords