Phosphine-Catalyzed Asymmetric Intermolecular Cross-Vinylogous Rauhut–Currier Reactions of Vinyl Ketones with para-Quinone Methides
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DOI: 10.1021/acscatal.7b00030
Abstract: A chiral amide-phosphine bifunctional catalyst was developed and successfully applied to the asymmetric intermolecular cross-vinylogous Rauhut–Currier of alkyl vinyl ketones with para-quinone methides, offering excellent regioselectivity and stereoselectivity (up to >99% enantiomeric excess (ee)). This… read more here.
Keywords: vinyl ketones; vinylogous rauhut; cross vinylogous; rauhut currier ... See more keywords
The Catalytic Asymmetric Intermolecular Prins Reaction
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DOI: 10.1021/jacs.1c10245
Abstract: Despite their significant potential, catalytic asymmetric reactions of olefins with formaldehyde are rare and metal-free approaches have not been previously disclosed. Here we describe an enantioselective intermolecular Prins reaction of styrenes and paraformaldehyde to form… read more here.
Keywords: catalytic asymmetric; intermolecular prins; prins reaction; asymmetric intermolecular ... See more keywords
Asymmetric Intermolecular Iodinative Difunctionalization of Allylic Sulfonamides Enabled by Organosulfide Catalysis: Modular Entry to Iodinated Chiral Molecules.
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DOI: 10.1021/jacs.2c05668
Abstract: Electrophilic halogenation of alkenes is a powerful transformation offering a convenient route for the construction of valuable functionalized molecules. However, as a highly important reaction in this field, catalytic asymmetric intermolecular iodinative difunctionalization remains a… read more here.
Keywords: iodinative difunctionalization; chiral molecules; allylic sulfonamides; difunctionalization ... See more keywords