Dual-reagent organophosphine catalyzed asymmetric Mannich reactions of isocyanoacetates with N -Boc-aldimines
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron"
DOI: 10.1016/j.tet.2017.08.031
Abstract: Abstract A combination of an amino-acid derived chiral phosphine catalyst and methyl acrylate has been employed to catalyze the direct Mannich reaction of α-aryl isocyanoacetate and N-Boc-aldimines efficiently. The loading of the catalyst could be… read more here.
Keywords: catalyzed asymmetric; boc aldimines; reagent organophosphine; dual reagent ... See more keywords
Catalytic Asymmetric Mannich Type Reaction with Tri-/Difluoro- or Trichloroacetaldimine Precursors.
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DOI: 10.1021/acs.orglett.8b03083
Abstract: A highly efficient catalytic asymmetric Mannich type reaction of CF3-, CF2H-, or CCl3-acetaldimine precursors by a chiral primary amine is presented. This protocol provides facile access to chiral CF3-, CF2H-, or trichloroethyl amines in excellent… read more here.
Keywords: mannich type; catalytic asymmetric; type reaction; asymmetric mannich ... See more keywords
α-Halo Amides as Competent Latent Enolates: Direct Catalytic Asymmetric Mannich-Type Reaction.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b03291
Abstract: α-Halogenated carbonyl compounds are susceptible to dehalogenation and thus largely neglected as enolate precursors in catalytic enantioselective C-C bond-forming reactions. By merging the increased stability of the α-C-halogen bond of amides and the direct enolization… read more here.
Keywords: direct catalytic; type reaction; mannich type; catalytic asymmetric ... See more keywords
A solid-supported organocatalyst for asymmetric Mannich reaction to construct C2-quaternary indolin-3-ones
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DOI: 10.1039/d2ra00456a
Abstract: A simple and novel solid-supported organocatalyst from a 2-chlorotrityl chloride resin-immobilized 4-hydroxyproline was developed, and this organocatalyst has been used for the asymmetric Mannich reaction of 2-aryl-3H-indol-3-ones and aldehydes/ketones. A series of C2-quaternary indolin-3-ones were… read more here.
Keywords: mannich reaction; quaternary indolin; supported organocatalyst; asymmetric mannich ... See more keywords