Asymmetric Organocatalysis and Photoredox Catalysis for the α‐Functionalization of Tetrahydroisoquinolines
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.201800117
Abstract: H. H. and S. Z. are grateful to the Chinese Scholarship Council for fellowships. The research leading to these results has received funding from the European Research Council under the European Union's Seventh Framework Programme… read more here.
Keywords: functionalization tetrahydroisoquinolines; asymmetric organocatalysis; chemistry; organocatalysis photoredox ... See more keywords
Recent Developments and Trends in Asymmetric Organocatalysis
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.202200950
Abstract: Abstract Asymmetric organocatalysis has experienced a long and spectacular way since the early reports over a century ago by von Liebig, Knoevenagel and Bredig, showing that small (chiral) organic molecules can catalyze (asymmetric) reactions. This… read more here.
Keywords: trends asymmetric; chemistry; recent developments; asymmetric organocatalysis ... See more keywords
Asymmetric Organocatalyzed Intermolecular Functionalization of Cyclohexanone-Derived Dienones.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical record"
DOI: 10.1002/tcr.202300042
Abstract: Over the past decades, the advent of asymmetric organocatalysis has changed the way chemists think about creating or breaking chemical bonds, enabling new enantioselective strategies for functionalized molecules. The success of asymmetric organocatalysis is notably… read more here.
Keywords: cyclohexanone derived; derived dienones; intermolecular functionalization; cyclohexanone ... See more keywords
Asymmetric Organocatalysis in the Remote (3 + 2)-Cycloaddition to 4-(Alk-1-en-1-yl)-3-cyanocoumarins
Sign Up to like & getrecommendations! Published in 2023 at "Organic Letters"
DOI: 10.1021/acs.orglett.3c01189
Abstract: The application of organocatalytic bifunctional activation in the remote (3 + 2)-cycloaddition between 4-(alk-1-en-1-yl)-3-cyanocoumarins and imines derived from salicylaldehyde is demonstrated. Products, bearing two biologically relevant units, have been obtained with good chemical and stereochemical… read more here.
Keywords: remote cycloaddition; alk cyanocoumarins; cycloaddition alk; asymmetric organocatalysis ... See more keywords
Asymmetric Organocatalysis Combined with Palladium Catalysis: Synergistic Effect on Enantioselective Mannich/α-Allylation Sequential Reactions of Pyrazolones in Constructing Vicinal Quaternary Stereocenters.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b02440
Abstract: In this letter, an efficient one-pot asymmetric sequential reaction is achieved by organo/transition metal relay catalysis in constructing two consecutive C-C bonds, which involves enantioselective amino squaramide catalytic Mannich-type addition of pyrazolones to isatin-derived ketimines… read more here.
Keywords: methodology; organocatalysis combined; asymmetric organocatalysis; palladium catalysis ... See more keywords
Advances in asymmetric organocatalysis over the last 10 years
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DOI: 10.1038/s41467-020-17580-z
Abstract: Beyond esoteric interest, organocatalysis has now become one major pillar of asymmetric catalysis. Here, we discuss how new activation modes are conquering challenging stereoselective transformations and the recent integration of organocatalysis with emerging photo- and… read more here.
Keywords: asymmetric organocatalysis; advances asymmetric; organocatalysis last; catalysis ... See more keywords
Asymmetric organocatalysis in drug discovery and development for active pharmaceutical ingredients
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2023.2160437
Abstract: ABSTRACT Introduction Over the last 20 years, it has become clear that organocatalysis is the third pillar of catalysis. The low reactivity in the early days of organocatalysis has been overcome with the invention of… read more here.
Keywords: drug discovery; development; asymmetric organocatalysis; active pharmaceutical ... See more keywords
Asymmetric Organocatalysis: A Survival Guide to Medicinal Chemists
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules28010271
Abstract: Majority of drugs act by interacting with chiral counterparts, e.g., proteins, and we are, unfortunately, well-aware of how chirality can negatively impact the outcome of a therapeutic regime. The number of chiral, non-racemic drugs on… read more here.
Keywords: medicinal chemists; organocatalysis survival; survival guide; chemistry ... See more keywords