Chiral Brønsted acid catalyzed asymmetric oxidation of N-acyl sulfenamide by H2 O2 : An efficient approach to obtaining chiral N-acyl sulfinamide.
Sign Up to like & getrecommendations! Published in 2022 at "Chirality"
DOI: 10.1002/chir.23478
Abstract: Although the power of chiral sulfinamide reagents in synthetic chemistry has long been recognized, methods for their synthesis are still auxiliary-based approaches which possess the disadvantages of poor atom economy and limited substrate universality. Due… read more here.
Keywords: chiral nsted; catalyzed asymmetric; nsted acid; acid ... See more keywords
Going Green in Process Chemistry: Optimizing an Asymmetric Oxidation Reaction To Synthesize the Antiulcer Drug Esomeprazole
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Chemical Education"
DOI: 10.1021/acs.jchemed.9b00350
Abstract: Sustainable practices in process chemistry are highlighted by a novel, 9 week team project of 8–12 students, in collaboration with AstraZeneca chemists, in an organic chemistry laboratory. Students synthesize the antiulcer medicine esomeprazole, which involves… read more here.
Keywords: asymmetric oxidation; process chemistry; chemistry; synthesize antiulcer ... See more keywords
Late-stage modification of π-electron systems based on asymmetric oxidation of a medium-sized sulfur-containing ring.
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DOI: 10.1039/d1cc06996a
Abstract: The asymmetric oxidation of a sulfur-containing nine-membered heterocycle was achieved for the late-stage introduction of chirality to the substituents of π-electron systems. The oxidation of the sulfur atom considerably influenced the phase-transition behaviour and crystallinity… read more here.
Keywords: oxidation; electron systems; sulfur containing; late stage ... See more keywords
Asymmetric oxidation of sulfides catalyzed by (R)-6,6'-dibromo-BINOL derived titanium complex
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DOI: 10.1080/00397911.2020.1786121
Abstract: Abstract An efficient asymmetric oxidation of sulfides was achieved using (R)-6,6'-dibromo-BINOL as chiral ligand in combination with Ti(OiPr)4 using 70% aqueous tertiary butyl hydroperoxide as oxidant. The resulting sulfoxides had high enantiopurities and good yields.… read more here.
Keywords: oxidation sulfides; asymmetric oxidation; sulfides catalyzed; dibromo binol ... See more keywords