Semi‐rational protein engineering of a novel ene‐reductase from Galdieria sulphuraria for asymmetric reduction of (R)‐carvone and ketoisophorone
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.2391
Abstract: Asymmetric reduction of (R)‐carvone and ketoisophorone by an engineered ene‐reductase from Galdieria sulphuraria (GsOYE) combined with glucose dehydrogenase for NADPH regeneration were studied. A semi‐rational protein engineering was used to enhance the activity and selectivity… read more here.
Keywords: reduction; reduction carvone; carvone ketoisophorone; asymmetric reduction ... See more keywords
Effect of organic solvents on asymmetric reduction of β-keto esters using cyanobacterium Synechocystis sp. PCC 6803
Sign Up to like & getrecommendations! Published in 2021 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2021.153249
Abstract: Abstract The asymmetric reduction of tert-butyl 3-oxobutanoate by cyanobacterium Synechocystis sp. PCC 6803 under illumination with red LED light at 25 °C for 24 h afforded the corresponding (R)-β-hydroxy ester in 79% enantiomeric excess (ee) (81% yield),… read more here.
Keywords: organic solvents; pcc 6803; cyanobacterium synechocystis; synechocystis pcc ... See more keywords
Identification of an Imine Reductase for Asymmetric Reduction of Bulky Dihydroisoquinolines.
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DOI: 10.1021/acs.orglett.7b01274
Abstract: A new imine reductase from Stackebrandtia nassauensis (SnIR) was identified, which displayed over 25- to 1400-fold greater catalytic efficiency for 1-methyl-3,4-dihydroisoquinoline (1-Me DHIQ) compared to other imine reductases reported. Subsequently, an efficient SnIR-catalyzed process was… read more here.
Keywords: imine reductase; reductase; identification imine; reduction bulky ... See more keywords
Copper-Catalyzed Asymmetric Reduction of β,β-Disubstituted Alkenylboramides.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b03400
Abstract: A highly enantioselective copper-catalyzed reduction of β,β-disubstituted alkenylboron compounds was developed using hydrosilane. The copper hydride catalyst coordinated with chiral Josiphos ligand efficiently discriminated β-geminal substituents to generate corresponding β-chiral alkylboramides with excellent enantioselectivities up… read more here.
Keywords: reduction; catalyzed asymmetric; reduction disubstituted; asymmetric reduction ... See more keywords