Ni-Catalyzed Asymmetric Reductive Alkenylation of α-Chlorosulfones with Vinyl Bromides.
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DOI: 10.1021/acs.orglett.2c00217
Abstract: A nickel-catalyzed enantioconvergent reductive cross-coupling of α-chlorosulfones with vinyl bromides is described here. This strategy enables the enantioselective construction of chiral allylic sulfones from simple α-chlorosulfones and vinyl bromides. The mild reaction conditions lead to… read more here.
Keywords: chlorosulfones vinyl; vinyl bromides; asymmetric reductive; reductive alkenylation ... See more keywords
1,2-Diamines as the Amine Sources in Amidation and Rhodium-Catalyzed Asymmetric Reductive Amination Cascade Reactions.
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DOI: 10.1021/acs.orglett.2c01728
Abstract: The sturdy chelation of 1,2-diamines and transition-metals would retard or even interrupt the routine catalytic cycles. In the amidation and asymmetric reductive amination (ARA) cascade reactions of diamines and ketoesters, we deployed sets of additives… read more here.
Keywords: asymmetric reductive; reductive amination; amidation; cascade reactions ... See more keywords
Asymmetric Reductive Amination with Pinacolborane Catalyzed by Chiral SPINOL Borophosphates.
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DOI: 10.1021/acs.orglett.2c03866
Abstract: The catalytic asymmetric reductive amination of ketones with pinacolborane employing chiral SPINOL-derived borophosphates as catalysts has been realized. A series of chiral amine derivatives bearing multiple functional groups were obtained in good to excellent yields… read more here.
Keywords: asymmetric reductive; reductive amination; chiral spinol; amination pinacolborane ... See more keywords
Kinetic Resolution to Simultaneously Access Both Primary and Secondary NH-Unprotected Chiral Amines via Ir-Catalyzed Asymmetric Reductive Amination.
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DOI: 10.1021/acs.orglett.5c01047
Abstract: This report describes a new kinetic resolution-asymmetric reductive amination strategy to collectively gain access to both primary and secondary chiral NH-unprotected amines. Catalyzed by the complex of iridium and bulky and tunable phosphoramidite ligands, various… read more here.
Keywords: reductive amination; access primary; primary secondary; kinetic resolution ... See more keywords
Photoassisted Cobalt-Catalyzed Asymmetric Reductive Grignard-Type Addition of Aryl Iodides.
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DOI: 10.1021/jacs.2c02481
Abstract: Grignard addition is one of the most important methods used for syntheses of alcohol compounds and has been known for over a hundred years. However, research on asymmetric catalysis relies on the use of organometallic… read more here.
Keywords: cobalt catalyzed; addition; asymmetric reductive; reductive grignard ... See more keywords
Asymmetric reductive arylation and alkenylation to access S-chirogenic sulfinamides
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DOI: 10.1038/s41467-025-57471-9
Abstract: The study of the stereochemistry of organic sulfur compounds has been ongoing for over a century, with S-chirogenic pharmacophores playing an essential role in drug discovery within bioscience and medicinal chemistry. Traditionally, the synthesis of… read more here.
Keywords: chemistry; chirogenic sulfinamides; reductive arylation; aryl alkenyl ... See more keywords
Secondary amines as coupling partners in direct catalytic asymmetric reductive amination† †Electronic supplementary information (ESI) available: Procedures and spectra. See DOI: 10.1039/c9sc00323a
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DOI: 10.1039/c9sc00323a
Abstract: Direct asymmetric reductive amination utilizing secondary amines as an efficient tool for one-step construction of tertiary chiral amines. read more here.
Keywords: amines coupling; secondary amines; coupling partners; asymmetric reductive ... See more keywords
Nickel-catalyzed asymmetric reductive aryl-allylation of unactivated alkenes†
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DOI: 10.1039/d1sc01115d
Abstract: Herein we report a nickel-catalyzed asymmetric reductive aryl-allylation of aryl iodide-tethered unactivated alkenes, wherein both acyclic allyl carbonates and cyclic vinyl ethylene carbonates can serve as the coupling partners. Furthermore, the direct use of allylic… read more here.
Keywords: aryl allylation; nickel catalyzed; catalyzed asymmetric; reductive aryl ... See more keywords