Rate volatility and asymmetric segregation diversify mutation burden in cells with mutator alleles
Sign Up to like & getrecommendations! Published in 2021 at "Communications Biology"
DOI: 10.1038/s42003-020-01544-6
Abstract: Mutations that compromise mismatch repair (MMR) or DNA polymerase ε or δ exonuclease domains produce mutator phenotypes capable of fueling cancer evolution. Here, we investigate how combined defects in these pathways expands genetic heterogeneity in… read more here.
Keywords: asymmetric segregation; rate; mutation burden; diversify mutation ... See more keywords