An Asymmetric Synthesis of (+)-Isostrychnine Based on Catalytic Asymmetric Tandem Double Michael Addition.
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DOI: 10.1021/acs.orglett.1c01828
Abstract: Herein, a concise asymmetric synthesis of (+)-isostrychnine is achieved in nine longest-linear steps with a 16% overall yield. The key features of this synthesis include the catalytic asymmetric tandem double Michael addition of a tryptamine-derived… read more here.
Keywords: tandem double; asymmetric tandem; synthesis isostrychnine; double michael ... See more keywords
Catalytic Asymmetric Tandem Reaction of o-Alkynylbenzaldehydes, Amines, and Diazo Compounds.
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DOI: 10.1021/acs.orglett.1c02433
Abstract: An efficient asymmetric tandem reaction of o-alkynylbenzaldehydes, amines, and diazo compounds catalyzed by chiral silver imidodiphosphate has been established. Chiral 1,2-dihydroisoquinoline analogues have a tertiary stereocenter at the C1 position, and substituents at the C3… read more here.
Keywords: amines diazo; asymmetric tandem; tandem reaction; diazo compounds ... See more keywords
Constructing chiral bicyclo[3.2.1]octanes via palladium-catalyzed asymmetric tandem Heck/carbonylation desymmetrization of cyclopentenes
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DOI: 10.1038/s41467-020-16221-9
Abstract: Transition-metal-catalyzed tandem Heck/carbonylation reaction has emerged as a powerful tool for the synthesis of structurally diverse carbonyl molecules, as well as natural products and pharmaceuticals. However, the asymmetric version was rarely reported, and remains a… read more here.
Keywords: tandem heck; asymmetric tandem; heck carbonylation;
Diastereo- and enantioselective construction of chiral cyclopenta[b]indole framework via a catalytic asymmetric tandem cyclization of 2-indolymethanols with 2-naphthols
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DOI: 10.1039/c8qo00014j
Abstract: A catalytic asymmetric tandem cyclization of 2-indolymethanols with 2-naphthols has been established in the presence of chiral phosphoric acids, which constructed chiral cyclopenta[b]indole frameworks in generally good yields (up to 90%), high diastereoselectivities (up to… read more here.
Keywords: cyclopenta indole; asymmetric tandem; chemistry; catalytic asymmetric ... See more keywords