Iridium-catalyzed asymmetric trans-selective hydrogenation of 1,3-disubstituted isoquinolines
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DOI: 10.1039/d1sc06729j
Abstract: The development of the first asymmetric trans-selective hydrogenation of 1,3-disubstituted isoquinolines is reported. Utilizing [Ir(cod)Cl]2 and a commercially available chiral Josiphos ligand, a variety of differentially substituted isoquinolines are hydrogenated to produce enantioenriched trans-tetrahydroisoquinolines in… read more here.
Keywords: hydrogenation disubstituted; hydrogenation; disubstituted isoquinolines; asymmetric trans ... See more keywords